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1. 发明专利

GB239489A Improvements in check valves 未知
公开(公告)号：GB239489A
公开(公告)日：1926-03-18
申请号：GB1487725
申请日：1925-06-08
申请人： EDWARD THAYER ADAMS
IPC分类号： F16K15/03
摘要： 239,489. Adams, E. T. Sept. 2, 1924, [Convention date]. Check hinged valves. - A hinged non-return valve has the arm supporting the valve member pivoted to a removable ring disposed laterally of the line or flow and held against a shoulder in the casing by a detachable cover. The cupped valve disc 11 co-operates with a seat 10 and is rotatably secured to the arm 16 by a nut 13 engaging a screwed projection 18 on the. back of the valve. The projection is provided with a slot 17 to facilitate grinding and the face of the valve has a square projection 12 for holding the valve against rotation when applying the nut 13. The supporting ring 5 is held against the shoulder 6 by a faced part 7 on the cap 8 and has a series of radial arms 24. One of these arms has a depending rectangular wall 23 the sides of which are formed with ears adapted to receive a pin 20 which also passes through the end of the arm 16. The pin is held against displacement by projections on the casing engaging the sides of the ears. The casing has hexagonal ends 2, 3 having a flat surface at the bottom of the valve.

2. 发明授权

US07299135B2 Methods for identifying discrete populations (e.g., clusters) of data within a flow cytometer multi-dimensional data set 失效
标题翻译：用于识别流式细胞仪多维数据集中的数据的离散群体（例如，簇）的方法
公开(公告)号：US07299135B2
公开(公告)日：2007-11-20
申请号：US11271316
申请日：2005-11-10
申请人： Edward Thayer
发明人： Edward Thayer
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N15/1459 , G01N2015/008 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , G06F19/00 , G06K9/00147 , G06K9/6226 , G06K9/626 , G16H50/20 , G16H50/70
摘要： Systems and methods for identifying populations of events in a multi-dimensional data set are described. The populations may, for example, be sets or clusters of data representing different white blood cell components in sample processed by a flow cytometer. The methods use a library consisting of one or more one finite mixture models, each model representing multi-dimensional Gaussian probability distributions with a density function for each population of events expected in the data set. The methods further use an expert knowledge set including one or more data transformations and one or more logical statements. The transformations and logical statements encode a priori expectations as to the populations of events in the data set. The methods further use program code by which a computer may operate on the data, a finite mixture model selected from the library, and the expert knowledge set to thereby identify populations of events in the data set.
摘要翻译：描述用于识别多维数据集中的事件群体的系统和方法。例如，种群可以是由流式细胞仪处理的样品中代表不同白细胞组分的数据集或簇。该方法使用由一个或多个有限混合模型组成的库，每个模型表示数据集中预期的每个事件群的密度函数的多维高斯概率分布。所述方法还使用包括一个或多个数据变换和一个或多个逻辑语句的专家知识集。变换和逻辑语句编码了对数据集中的事件群体的先验期望。这些方法还使用计算机可以对数据进行操作的程序代码，从库中选择的有限混合模型和专家知识集合，从而识别数据集中的事件群体。

3. 发明申请

US20050239166A1 Polynucleotides encoding human secreted protein, ZZP1 审中-公开
标题翻译：编码人分泌蛋白的多核苷酸ZZP1
公开(公告)号：US20050239166A1
公开(公告)日：2005-10-27
申请号：US11095261
申请日：2005-03-31
申请人： Edward Thayer , Philippa Webster
发明人： Edward Thayer , Philippa Webster
IPC分类号： A61P15/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07H21/04 , C07K14/585
CPC分类号： C07K14/47 , Y10S530/853
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for Zzp1, a novel Zona Pellucida protein. The polypeptides, and polynucleotides encoding them, are fertility modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the Zzp1 polypeptides.
摘要翻译：本发明涉及Zzp1，一种新型的Zona Pellucida蛋白的多核苷酸和多肽分子及其变体。多肽和编码它们的多核苷酸是调节生育力并可用于递送和治疗。本发明还包括针对Zzp1多肽的抗体。

4. 发明申请

US20080108510A1 Method for estimating error from a small number of expression samples 审中-公开
标题翻译：用于从少量表达样本估计误差的方法
公开(公告)号：US20080108510A1
公开(公告)日：2008-05-08
申请号：US11592006
申请日：2006-11-02
申请人： Edward Thayer
发明人： Edward Thayer
IPC分类号： C40B30/02
CPC分类号： G16B25/00
摘要： A method for estimating error in expression data. In one embodiment, the method includes single molecule sequencing a plurality of expression tags from an organism; removing expression tags that ambiguously relate to multiple genes; assigning each remaining expression tag to a respective gene; selecting a random subset of the expression tags; and counting the number of expression tags associated with each gene. The process of selecting a random subset of the expression tags; and counting the number of expression tags associated with each gene is repeated a predetermined number of times, both for expression tags sequenced before and after exposure of the organism to a perturbation. The method also includes the step of calculating a measure of error in response to the counts of the number of expression tags before and after the perturbation.
摘要翻译：一种估计表达数据误差的方法。在一个实施方案中，该方法包括从生物体单个分子测序多个表达标签; 去除与多个基因无关的表达标签; 将每个剩余的表达标签分配给相应的基因; 选择表达标签的随机子集; 并计算与每个基因相关联的表达标签的数量。选择表达标签的随机子集的过程; 并且将与每个基因相关联的表达标签的数量计数重复预定次数，两者对于在生物体暴露于扰动之前和之后测序的表达标签。该方法还包括响应于在扰动之前和之后的表达标签的数量的计数来计算误差量度的步骤。

5. 发明申请

US20050020497A1 Mammalian glycoprotein hormone-1 审中-公开
标题翻译：哺乳动物糖蛋白激素-1
公开(公告)号：US20050020497A1
公开(公告)日：2005-01-27
申请号：US10733597
申请日：2003-12-11
申请人： James Holloway , Philippa Webster , Edward Thayer
发明人： James Holloway , Philippa Webster , Edward Thayer
IPC分类号： A61K38/22 , C07K14/575 , C07K16/26 , A61K38/24
CPC分类号： C07K16/26 , A61K38/00 , C07K14/575
摘要： Mammalian glycoprotein hormone-1 (Zlut1) polypeptides, polynucleotides encoding the polypeptides, antibodies that specifically bind to the polypeptides, expression vectors comprised of the polynucleotides, and host cells transformed with the expression vectors.
摘要翻译：哺乳动物糖蛋白激素-1（Zlut1）多肽，编码多肽的多核苷酸，特异性结合多肽的抗体，由多核苷酸组成的表达载体和用表达载体转化的宿主细胞。

6. 发明申请

US20070118297A1 Methods for identifying discrete populations (e.g., clusters) of data within a flow cytometer multi-dimensional data set 失效
标题翻译：用于识别流式细胞仪多维数据集中的数据的离散群体（例如，簇）的方法
公开(公告)号：US20070118297A1
公开(公告)日：2007-05-24
申请号：US11271316
申请日：2005-11-10
申请人： Edward Thayer
发明人： Edward Thayer
IPC分类号： G06F19/00
CPC分类号： G01N15/1459 , G01N2015/008 , G01N2015/1006 , G01N2015/1402 , G01N2015/1477 , G06F19/00 , G06K9/00147 , G06K9/6226 , G06K9/626 , G16H50/20 , G16H50/70
摘要： Systems and methods for identifying populations of events in a multi-dimensional data set, e.g., seven dimensional flow cytometry data of a blood sample. The populations may, for example, be sets or clusters of data representing different white blood cell components in the sample. The methods use a library consisting of one or more one finite mixture models, each model component comprising parameters representing multi-dimensional Gaussian probability density functions, one density for each population of events expected in the data set. The methods further use an expert knowledge set comprising one or more data transformations for operation on the multi-dimensional data set and one or more logical statements. The transformations and logical statements encode a priori expectations as to the relationships between different event populations in the data set. The methods further use program code comprising instructions by which a processing unit such as a computer may operate on the multi-dimensional data, a finite mixture model selected from the library, and the expert knowledge set to thereby identify populations of events in the multi-dimensional data set.
摘要翻译：用于识别多维数据集中的事件群体的系统和方法，例如血液样品的七维流式细胞术数据。群体可以例如是样本中表示不同白细胞成分的数据集或数据集。该方法使用由一个或多个有限混合模型组成的库，每个模型组件包括表示多维高斯概率密度函数的参数，对于数据集中期望的每个事件群，一个密度。所述方法还使用包括用于对多维数据集和一个或多个逻辑语句进行操作的一个或多个数据变换的专家知识集合。转换和逻辑语句编码了数据集中不同事件群体之间的关系的先验期望。该方法进一步使用程序代码，其包括诸如计算机的处理单元可以对多维数据进行操作的指令，从库中选择的有限混合模型和专家知识集合，从而识别多维数据中的事件群体，维数据集。

7. 发明申请

US20070066811A1 ADIPOCYTE COMPLEMENT RELATED PROTEIN ZACRP3X2 审中-公开
标题翻译： ADIPOCYTE补充相关蛋白ZACRP3X2
公开(公告)号：US20070066811A1
公开(公告)日：2007-03-22
申请号：US11559108
申请日：2006-11-13
申请人： Betty Haldeman , Edward Thayer , Paul Sheppard
发明人： Betty Haldeman , Edward Thayer , Paul Sheppard
IPC分类号： C07K16/24
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/00
摘要： Novel zacrp3x2 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp3x2 protein or fragments thereof.
摘要翻译：公开了新的zacrp3x2多肽，编码多肽的多核苷酸，以及相关的组合物和方法。还公开了针对zacrp3x2蛋白或其片段的抗体。

8. 发明授权

US4054241A Tapered octagonal tray 失效
标题翻译：锥形八角盘
公开(公告)号：US4054241A
公开(公告)日：1977-10-18
申请号：US691879
申请日：1976-06-01
申请人： George Leroy Meyers , David Charles Mueller , Edward Thayer Elliott
发明人： George Leroy Meyers , David Charles Mueller , Edward Thayer Elliott
IPC分类号： B65D5/20 , B65D5/28
CPC分类号： B65D5/28 , B65D5/2033
摘要： A nestable octagonal tray having tapered, glued side walls of low height. The tray has an octagonal bottom panel, four trapezoidal side walls each attached at its shorter parallel edge to the bottom panel, four trapezoidal side flaps each attached at its longer parallel edge to the bottom panel, and eight substantially rectangular glue flaps each attached along its base to one of the non-parallel sides of the trapezoidal side walls. The side flaps and glue flaps are adhered in overlapping relation.
摘要翻译：一个可嵌套的八角形托盘，其具有低高度的锥形胶合侧壁。托盘具有八角形底板，四个梯形侧壁各自在其较短的平行边缘附接到底板，四个梯形侧翼各自在其较长的平行边缘附接到底板，以及八个基本上矩形的胶片，每个沿其沿着基座到梯形侧壁的非平行侧之一。侧翼和胶片以重叠的关系粘附。

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