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1. 发明授权

US09133516B2 Methods for identification of alleles using allele-specific primers for amplification 有权
标题翻译：使用等位基因特异性引物鉴定等位基因进行扩增的方法
公开(公告)号：US09133516B2
公开(公告)日：2015-09-15
申请号：US12305193
申请日：2007-06-29
申请人： Caixia Li , Huafang Gao , Xiang Liu , Bin Cai , Di Zhang , Jing Cheng
发明人： Caixia Li , Huafang Gao , Xiang Liu , Bin Cai , Di Zhang , Jing Cheng
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16 , C12Q2565/501 , C12Q2535/125 , C12Q2525/161
摘要： The invention provides a method for identification of alleles. In this method, genomic DNA is used as target. Multiple allele-specific PCR amplification are carried out with a group of primers comprising one or more allele-specific primers for a target gene, a universal primer, and a common primer; and a DNA polymerase without 5′ to 3′ exonuclease activity. The PCR products are hybridized with tag probes immobilized on a DNA chip. Results are determined based on the signal intensity and the position of the probe immobilized on the array. Each allele-specific primer comprises a unique tag sequence at the 5′ end. Each tag probe immobilized on the DNA chip comprises a sequence identical to its corresponding tag sequence; and each tag probe hybridizes only with the complementary sequence in the PCR amplification product.
摘要翻译：本发明提供了一种鉴定等位基因的方法。在该方法中，使用基因组DNA作为靶。使用包含靶基因，通用引物和通用引物的一个或多个等位基因特异性引物的引物组进行多重等位基因特异性PCR扩增; 和没有5'至3'外切核酸酶活性的DNA聚合酶。 PCR产物与固定在DNA芯片上的标签探针杂交。结果基于信号强度和固定在阵列上的探针的位置来确定。每个等位基因特异性引物包含在5'末端的唯一标签序列。固定在DNA芯片上的每个标签探针包含与其相应的标签序列相同的序列; 并且每个标签探针仅与PCR扩增产物中的互补序列杂交。

2. 发明申请

US20100041563A1 METHODS FOR IDENTIFICATION OF ALLELES 有权
标题翻译：方法识别对象
公开(公告)号：US20100041563A1
公开(公告)日：2010-02-18
申请号：US12305193
申请日：2007-06-29
申请人： Caixia Li , Huafang Gao , Xiang Liu , Bin Cai , Di Zhang , Jing Cheng
发明人： Caixia Li , Huafang Gao , Xiang Liu , Bin Cai , Di Zhang , Jing Cheng
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16 , C12Q2565/501 , C12Q2535/125 , C12Q2525/161
摘要： The invention provides a method for identification of alleles. In this method, genomic DNA is used as target. Multiple allele-specific PCR amplification are carried out with a group of primers comprising one or more allele-specific primers for a target gene, a universal primer, and a common primer; and a DNA polymerase without 5′ to 3′ exonuclease activity. The PCR products are hybridized with tag probes immobilized on a DNA chip. Results are determined based on the signal intensity and the position of the probe immobilized on the array. Each allele-specific primer comprises a unique tag sequence at the 5′ end. Each tag probe immobilized on the DNA chip comprises a sequence identical to its corresponding tag sequence; and each tag probe hybridizes only with the complementary sequence in the PCR amplification product.
摘要翻译：本发明提供了一种鉴定等位基因的方法。在该方法中，使用基因组DNA作为靶。使用包含靶基因，通用引物和通用引物的一个或多个等位基因特异性引物的引物组进行多重等位基因特异性PCR扩增; 和没有5'至3'外切核酸酶活性的DNA聚合酶。 PCR产物与固定在DNA芯片上的标签探针杂交。结果基于信号强度和固定在阵列上的探针的位置来确定。每个等位基因特异性引物包含在5'末端的唯一标签序列。固定在DNA芯片上的每个标签探针包含与其相应的标签序列相同的序列; 并且每个标签探针仅与PCR扩增产物中的互补序列杂交。

3. 发明申请

US20060088519A1 Malignant tumor-inhibiting preparation comprising Des A fibrin 审中-公开
公开(公告)号：US20060088519A1
公开(公告)日：2006-04-27
申请号：US11314443
申请日：2005-12-21
申请人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
发明人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
IPC分类号： A61K38/48
CPC分类号： A61K38/363
摘要： A malignant tumor-inhibiting preparation is provided which comprises Des A fibrin and therefore can inhibit the spreading and migration of malignant tumor cells and thereby can inhibit the malignant tumors.

4. 发明授权

US08481047B2 Malignant tumor-inhibiting preparation comprising Des A fibrin 有权
标题翻译：包含Des A纤维蛋白的恶性肿瘤抑制制剂
公开(公告)号：US08481047B2
公开(公告)日：2013-07-09
申请号：US11818783
申请日：2007-06-15
申请人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
发明人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
IPC分类号： A61K39/385
CPC分类号： A61K38/363
摘要： A malignant tumor-inhibiting preparation is provided which comprises Des A fibrin and therefore can inhibit the spreading and migration of malignant tumor cells and thereby can inhibit the malignant tumors.
摘要翻译：提供了一种恶性肿瘤抑制制剂，其包含Des A纤维蛋白，因此可以抑制恶性肿瘤细胞的扩散和迁移，从而可以抑制恶性肿瘤。

5. 发明授权

US08257840B2 Security functional thin film and security product containing the functional thin film 有权
标题翻译：安全功能薄膜和安全产品，含有功能薄膜
公开(公告)号：US08257840B2
公开(公告)日：2012-09-04
申请号：US12305966
申请日：2008-03-24
申请人： Xiaowei Li , Xinyu Li , Ce Li , Jing Yang , Feng Pan , Caixia Li , Yu Cao
发明人： Xiaowei Li , Xinyu Li , Ce Li , Jing Yang , Feng Pan , Caixia Li , Yu Cao
IPC分类号： B32B15/04
CPC分类号： B32B37/24 , B32B37/203 , B32B2037/246 , B32B2307/208 , B32B2309/105 , B32B2425/00 , B32B2429/00 , G09F3/0292 , G11B5/00808 , H01F10/132 , H01F41/18 , Y10T428/24802 , Y10T428/265 , Y10T428/325
摘要： The present invention provides a security functional thin film and a security product containing such a thin film. The security functional thin film is of an amorphous structure, and possesses soft magnetic characteristics. Large Barkhausen effect can be detected along the in-plane preferred direction of magnetization; and the Large Barkhausen effect significantly attenuates, or no such signal can be detected, in a direction perpendicular to the in-plane preferred direction of magnetization. The thin film has a thickness of 20-300 nm, and the thin film also possesses element encoding characteristics that can be authenticated by experts. The security functional thin film of the present invention can be fabricated by magnetron sputtering web coating process. The security product provided by the present invention has a security information layer formed of the security functional thin film, and can be combined with other security characteristics for use in fabricating security materials such as security threads, security tapes, paper security strip-like inserts, or security labels, and others. Compared with conventional anti-counterfeiting technologies, the instant security functional thin film has more hidden security information, and facilitates enhancement of safety performance of security products.
摘要翻译：本发明提供一种安全功能薄膜和包含这种薄膜的安全产品。安全功能薄膜为非晶结构，具有软磁特性。沿着平面内优选的磁化方向可以检测到大的巴克豪森效应; 并且大巴克豪森效应在垂直于面内优选磁化方向的方向上显着衰减或不能检测到这样的信号。该薄膜的厚度为20-300nm，薄膜还具有可由专家认证的元件编码特性。本发明的安全功能薄膜可以通过磁控溅射网涂布法制造。由本发明提供的安全产品具有由安全功能薄膜形成的安全信息层，并且可以与用于制造诸如安全螺纹，安全带，纸安全带状插入物等安全材料的其他安全特性组合，或安全标签等。与传统防伪技术相比，即时安全功能薄膜具有更多隐藏的安全信息，有利于提高安全产品的安全性能。

6. 发明申请

US20100220371A1 Security Functional Thin Film and Security Product Containing the Functional Thin Film 有权
标题翻译：安全功能薄膜和包含功能薄膜的安全产品
公开(公告)号：US20100220371A1
公开(公告)日：2010-09-02
申请号：US12305966
申请日：2008-03-24
申请人： Xiaowei Li , Xinyu Li , Ce Li , Jing Yang , Feng Pan , Caixia Li , Yu Cao
发明人： Xiaowei Li , Xinyu Li , Ce Li , Jing Yang , Feng Pan , Caixia Li , Yu Cao
IPC分类号： B42D15/10 , B32B5/00 , C23C14/34 , B32B9/04
CPC分类号： B32B37/24 , B32B37/203 , B32B2037/246 , B32B2307/208 , B32B2309/105 , B32B2425/00 , B32B2429/00 , G09F3/0292 , G11B5/00808 , H01F10/132 , H01F41/18 , Y10T428/24802 , Y10T428/265 , Y10T428/325
摘要： The present invention provides a security functional thin film and a security product containing such a thin film. The security functional thin film is of an amorphous structure, and possesses soft magnetic characteristics. Large Barkhausen effect can be detected along the in-plane preferred direction of magnetization; and the Large Barkhausen effect significantly attenuates, or no such signal can be detected, in a direction perpendicular to the in-plane preferred direction of magnetization. The thin film has a thickness of 20-300 nm, and the thin film also possesses element encoding characteristics that can be authenticated by experts. The security functional thin film of the present invention can be fabricated by magnetron sputtering web coating process. The security product provided by the present invention has a security information layer formed of the security functional thin film, and can be combined with other security characteristics for use in fabricating security materials such as security threads, security tapes, paper security strip-like inserts, or security labels, and others. Compared with conventional anti-counterfeiting technologies, the instant security functional thin film has more hidden security information, and facilitates enhancement of safety performance of security products.
摘要翻译：本发明提供一种安全功能薄膜和包含这种薄膜的安全产品。安全功能薄膜为非晶结构，具有软磁特性。沿着平面内优选的磁化方向可以检测到大的巴克豪森效应; 并且大巴克豪森效应在垂直于面内优选磁化方向的方向上显着衰减或不能检测到这样的信号。该薄膜的厚度为20-300nm，薄膜还具有可由专家认证的元件编码特性。本发明的安全功能薄膜可以通过磁控溅射网涂布法制造。由本发明提供的安全产品具有由安全功能薄膜形成的安全信息层，并且可以与用于制造诸如安全螺纹，安全带，纸安全带状插入物等安全材料的其他安全特性组合，或安全标签等。与传统防伪技术相比，即时安全功能薄膜具有更多隐藏的安全信息，有利于提高安全产品的安全性能。

7. 发明申请

US20090018062A1 Malignant tumor-inhibiting preparation comprising des a fibrin 有权
标题翻译：包含脱纤维蛋白的恶性肿瘤抑制制剂
公开(公告)号：US20090018062A1
公开(公告)日：2009-01-15
申请号：US11818783
申请日：2007-06-15
申请人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
发明人： Hirobumi Senga , Caixia Li , Yongling Wan , Lishui Chang
IPC分类号： A61K38/16 , A61P35/00
CPC分类号： A61K38/363
摘要： A malignant tumor-inhibiting preparation is provided which comprises Des A fibrin and therefore can inhibit the spreading and migration of malignant tumor cells and thereby can inhibit the malignant tumors.
摘要翻译：提供了一种恶性肿瘤抑制制剂，其包含Des A纤维蛋白，因此可以抑制恶性肿瘤细胞的扩散和迁移，从而可以抑制恶性肿瘤。

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