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1. 发明专利

AU2904292A BATTERY REPLACEMENT AND MAGNETIC PICKUP APPARATUS 未知
公开(公告)号：AU2904292A
公开(公告)日：1993-05-21
申请号：AU2904292
申请日：1992-10-22
申请人： CRAWFORD THOMAS C JR , JONES WILLIAM T JR
发明人： THOMAS C. CRAWFORD JR , WILLIAM T. JONES JR.
IPC分类号： B25B9/00 , B25B11/00
摘要： An apparatus for removing and replacing small batteries in electronic devices such as hearing aids or handling small magnetic parts has a housing in which a reciprocating shaft is placed having a magnet at one end. When the reciprocating shaft is placed in its extended pickup position, the magnet is brought close to the end of the housing, and into contact with the battery or other magnetic object. Once in contact with the object, the apparatus may be used for manipulation. Once the object is placed where it is to be left, the reciprocating shaft may be moved to a retracted position weakening the magnetic field holding the battery to the end of the apparatus. The reciprocating shaft is moved and locked into its extended and retracted positions with a rotating ratchet mechanism operated with a thumb of the hand that holds the apparatus. A shim in separable parts of the housing makes adjustment of the terminal end position of the magnet possible. A non-magnetic shield member or barrier layer surrounding the magnet at the tip effectively blocks the lateral attraction force so that only the object desired is picked up without disturbing surrounding objects.

2. 发明申请

WO2011063421A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY 审中-公开
标题翻译：基于CYCLODEXTRIN的治疗方法的聚合物
公开(公告)号：WO2011063421A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/057913
申请日：2010-11-23
申请人： CERULEAN PHARMA INC. , WOLFGANG, Marc , REITER, Lawrence, A. , CRAWFORD, Thomas, C. , FETZER, Oliver, S.
发明人： WOLFGANG, Marc , REITER, Lawrence, A. , CRAWFORD, Thomas, C. , FETZER, Oliver, S.
IPC分类号： A01N43/02 , A61K31/335
CPC分类号： A61K31/337 , A61K45/06 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/61 , A61K2300/00
摘要： Methods and compositions relating to CDP-taxane conjugates are described herein.
摘要翻译：本文描述了与CDP-紫杉烷共轭物有关的方法和组合物。

3. 发明申请

WO1993007988A1 BATTERY REPLACEMENT AND MAGNETIC PICKUP APPARATUS 审中-公开
标题翻译：电池更换和磁选设备
公开(公告)号：WO1993007988A1
公开(公告)日：1993-04-29
申请号：PCT/US1992009190
申请日：1992-10-22
申请人： CRAWFORD, Thomas, C., Jr. , JONES, William, T., Jr.
IPC分类号： B23P19/00
CPC分类号： B25B9/00 , B25B11/002 , Y10T29/4973 , Y10T29/49822 , Y10T29/53196 , Y10T29/53909
摘要： An apparatus (10) for removing and replacing small batteries in electronic devices such as hearing aids or handling small magnetic parts has a housing (15, 35) in which a reciprocating shaft (55) is placed having a magnet at one end. When the reciprocating shaft is extended, the magnet is brought into contact with the battery or other magnetic object. Once in contact with the object, the object is placed where it is to be left and the reciprocating shaft may be moved to a retracted position, thereby weakening the magnetic field holding the battery to the end of the apparatus. The reciprocating shaft is moved and locked into its extended and retracted positions with a rotating ratchet mechanism (53). A non-magnetic shield member (72) surrounding the magnet at the tip effectively blocks the lateral attraction force so that only the object desired is picked up without disturbing surrounding objects.
摘要翻译：一种用于移除和更换诸如助听器或处理小型磁性部件的电子设备中的小电池的设备（10）具有一个壳体（15,35），其中在一端具有磁铁的往复轴（55）放置在其中。当往复轴延伸时，磁体与电池或其他磁性物体接触。一旦与物体接触，物体被放置在要留下的地方，并且往复轴可以移动到缩回位置，从而削弱将电池保持在设备末端的磁场。往复运动轴通过旋转的棘轮机构（53）移动并锁定到其延伸和缩回的位置。围绕尖端的磁体的非磁性屏蔽构件（72）有效地阻挡了侧向吸引力，使得只有拾取所需的物体而不扰乱周围的物体。

4. 发明申请

WO1994016694A1 LYSINE SALT OF 6-CHLORO-5-FLUORO-3-(2-THENOYL)-2-OXINDOLE-1-CARBOXAMIDE 审中-公开
标题翻译：六氯-5-氟-3-（2-噻吩基）-2-氧杂-1-羧酰胺的赖氨酸盐
公开(公告)号：WO1994016694A1
公开(公告)日：1994-08-04
申请号：PCT/US1994000096
申请日：1994-01-06
申请人： PFIZER INC. , COOPER, Kelvin , CRAWFORD, Thomas, C. , LITTMAN, Bruce, H. , PAZOLES, Christopher, J. , RUGGERI, Sally, G. , WILNER, Keith, D.
发明人： PFIZER INC.
IPC分类号： A61K31/40
CPC分类号： C07D409/06 , A61K31/40
摘要： The lysine salt of 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide and a method of producing analgesia and treating anti-inflammatory disease in a human subject.
摘要翻译： 6-氯-5-氟-3-（2-噻吩甲酰基）-2-羟基吲哚-1-甲酰胺的赖氨酸盐以及在人类受试者中产生止痛和治疗抗炎疾病的方法。

5. 发明申请

WO1990004393A1 PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES 审中-公开
标题翻译：抗坏血酸3-亚氨基-2-氧杂-1-羧酸的产物
公开(公告)号：WO1990004393A1
公开(公告)日：1990-05-03
申请号：PCT/US1988003658
申请日：1988-10-18
申请人： PFIZER INC. , REITER, Lawrence, A. , CRAWFORD, Thomas, C.
发明人： PFIZER INC.
IPC分类号： A61K31/405
CPC分类号： C07D409/06 , C07D209/34 , C07F9/65586
摘要： Certain enol ethers and esters of formula (I), where X and Y are each hydrogen, fluoro or chloro; R is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, phenylalkanoyl, chlorobenzoyl, methoxybenzyl, phenyl, thenoyl, omega-alkoxycarbonylalkanoyl, alkoxycarbonyl, phenoxycarbonyl, 1-alkoxyalkyl, 1-alkoxy-carbonyloxyalkyl, alkyl, alkylsulfonyl, methylphenyl-sulfonyl or dialkylphosphonate are useful as prodrug forms the known 3-acyl-2-oxindole-1-carboxamide antiinflammatory and analgesic agents.
摘要翻译：某些式（I）的烯醇醚和酯，其中X和Y各自为氢，氟或氯; R 1是2-噻吩基或苄基，R是烷酰基，环烷基羰基，苯基烷酰基，氯苯甲酰基，甲氧基苄基，苯基，噻吩甲酰基，ω-烷氧基羰基烷酰基，烷氧基羰基，苯氧基羰基，1-烷氧基烷基，1-烷氧基 - 羰氧基烷基，烷基，烷基磺酰基，甲基苯基磺酰基或二烷基膦酸盐可用作前体化合物，形成已知的3-酰基-2-羟基吲哚-1-甲酰胺抗炎和止痛剂。

6. 发明申请

WO2010117668A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：聚合物共混物，颗粒，组合物和相关使用方法
公开(公告)号：WO2010117668A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/028770
申请日：2010-03-26
申请人： CERULEAN PHARMA INC. , ELIASOF, Scott , CRAWFORD, Thomas, C. , GANGEL, Geeti , REITER, Lawrence, Alan , NG, Pei-Sze
发明人： ELIASOF, Scott , CRAWFORD, Thomas, C. , GANGEL, Geeti , REITER, Lawrence, Alan , NG, Pei-Sze
IPC分类号： A61K9/00
CPC分类号： A61K47/48853 , A61B2018/00005 , A61K9/0019 , A61K9/14 , A61K9/19 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/482 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K49/0089 , A61M5/427 , A61P35/00
摘要： Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer- agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
摘要翻译：本文描述的是聚合物 - 试剂缀合物和颗粒，其可以用于例如癌症的治疗。本文还描述了含有颗粒的混合物，组合物和剂型，使用颗粒的方法（例如，治疗病症），包括聚合物 - 试剂缀合物和颗粒的试剂盒，制备聚合物 - 试剂缀合物和颗粒的方法，方法存储颗粒和分析颗粒的方法。

7. 发明申请

WO2010114770A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：聚合物共混物，颗粒，组合物和相关使用方法
公开(公告)号：WO2010114770A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/028831
申请日：2010-03-26
申请人： CERULEAN PHARMA INC. , ELIASOF, Scott , CRAWFORD, Thomas C. , GANGAL, Geeti , REITER, Lawrence Alan , NG, Pei-Sze
发明人： ELIASOF, Scott , CRAWFORD, Thomas C. , GANGAL, Geeti , REITER, Lawrence Alan , NG, Pei-Sze
IPC分类号： A61K31/80
CPC分类号： A61K47/482 , A61K9/14 , A61K9/1647 , A61K9/19 , A61K9/5138 , A61K31/337 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/765 , A61K31/80 , A61K47/593
摘要： Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
摘要翻译：本文描述的是聚合物 - 试剂缀合物和颗粒，其可以用于例如癌症的治疗。本文还描述了含有颗粒的混合物，组合物和剂型，使用颗粒的方法（例如，治疗病症），包括聚合物 - 试剂缀合物和颗粒的试剂盒，制备聚合物 - 试剂缀合物和颗粒的方法，方法存储颗粒和分析颗粒的方法。

8. 发明申请

WO2013025337A1 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY 审中-公开
标题翻译：基于环糊精的聚合物用于治疗性递送
公开(公告)号：WO2013025337A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/048865
申请日：2012-07-30
申请人： CERULEAN PHARMA INC. , CRAWFORD, Thomas, C. , FETZER, Oliver, S. , REITER, Lawrence, Alan , WOLFGANG, Marc
发明人： CRAWFORD, Thomas, C. , FETZER, Oliver, S. , REITER, Lawrence, Alan , WOLFGANG, Marc
IPC分类号： A61P35/00 , A61K31/337
CPC分类号： A61K47/40 , A61K31/337 , A61K45/06 , A61K47/55 , A61K47/59 , A61K47/60 , A61K47/61 , A61K2300/00
摘要： Methods and compositions relating to CDP-taxane conjugates are described herein.
摘要翻译：本文描述了涉及CDP-紫杉烷偶联物的方法和组合物。

9. 发明申请

WO2012050899A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：聚合物共混物，颗粒，组合物和相关使用方法
公开(公告)号：WO2012050899A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053716
申请日：2011-09-28
申请人： CERULEAN PHARMA INC. , CRAWFORD, Thomas, C. , ELIASOF, Scott , GANGAL, Geeti , NG, Pei-Sze , REITER, Lawrence, Alan , ZHANG, Jerry
发明人： CRAWFORD, Thomas, C. , ELIASOF, Scott , GANGAL, Geeti , NG, Pei-Sze , REITER, Lawrence, Alan , ZHANG, Jerry
IPC分类号： A61K9/14 , A61K31/765
CPC分类号： A61K9/0019 , A61K31/337 , A61K31/505 , A61K31/704 , A61K47/543 , A61K47/593 , A61K47/60
摘要： Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
摘要翻译：本文描述的是聚合物 - 试剂缀合物和颗粒，其可以用于例如癌症的治疗。本文还描述了含有颗粒的混合物，组合物和剂型，使用颗粒的方法（例如，治疗病症），包括聚合物 - 试剂缀合物和颗粒的试剂盒，制备聚合物 - 试剂缀合物和颗粒的方法，方法存储颗粒和分析颗粒的方法。

10. 发明申请

WO2010114768A1 POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：聚合物 - EPOTHILONE共混物，颗粒，组合物及相关使用方法
公开(公告)号：WO2010114768A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/028793
申请日：2010-03-26
申请人： CERULEAN PHARMA INC. , ELIASOF, Scott , CRAWFORD, Thomas, C. , GANGAL, Geeti , REITER, Lawrence, Alan , NG, Pei-sze
发明人： ELIASOF, Scott , CRAWFORD, Thomas, C. , GANGAL, Geeti , REITER, Lawrence, Alan , NG, Pei-sze
IPC分类号： A61K9/127
CPC分类号： A61K47/48915 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6921 , A61K47/6925 , B82Y5/00
摘要： Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer or neurological deficits. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer- agent conjugates and particles, methods of storing the particles and methods of analyzing the particles.
摘要翻译：本文描述的是聚合物 - 试剂缀合物和颗粒，其可以用于例如治疗癌症或神经缺陷。本文还描述了含有颗粒的混合物，组合物和剂型，使用颗粒的方法（例如，治疗病症），包括聚合物 - 试剂缀合物和颗粒的试剂盒，制备聚合物 - 试剂缀合物和颗粒的方法，方法存储颗粒和分析颗粒的方法。

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