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1. 发明申请

WO2009015104A3 IMPLANTABLE DEVICES AND METHODS FOR EXTERNAL BEAM RADIATION TREATMENTS 审中-公开
标题翻译：可植入装置和用于外部束辐射治疗的方法
公开(公告)号：WO2009015104A3
公开(公告)日：2009-08-13
申请号：PCT/US2008070682
申请日：2008-07-21
申请人： CALYPSO MED TECHNOLOGIES INC , NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
发明人： NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
IPC分类号： A61B19/00
CPC分类号： A61N5/1049 , A61N2005/1051
摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.
摘要翻译：公开了用于外部射束辐射处理的可植入装置和方法。用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线传输的源能量而传输非电离无线信号的有源标记器。该装置进一步包括紧固单元，该紧固单元联接到有源标记并且被配置为（a）将标记保持在组织中目标的期望距离内，以及（b）抑制组织相对于目标移动有源标记的变形。

2. 发明申请

WO2006094156B1 SYSTEMS AND METHODS FOR TREATING A PATIENT USING GUIDED RADIATION THERAPY OR SURGERY 审中-公开
标题翻译：使用引导辐射治疗或手术治疗患者的系统和方法
公开(公告)号：WO2006094156B1
公开(公告)日：2007-12-21
申请号：PCT/US2006007508
申请日：2006-03-02
申请人： CALYPSO MED TECHNOLOGIES INC , MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
发明人： MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
IPC分类号： A61B19/00
CPC分类号： A61B90/16 , A61B34/20 , A61B34/25 , A61B90/14 , A61B90/39 , A61B2034/2051 , A61B2090/101 , A61B2090/363 , A61B2090/374 , A61B2090/3975 , A61B2090/3995
摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.
摘要翻译：用于定位和跟踪目标的系统和方法，即在用于头颈部的引导放射治疗应用中，在患者的建立和治疗期间测量目标的位置和/或旋转。一个实施例涉及具有身体和标记的装置，例如可固定在体内或身体上用于定位身体的可兴奋的应答器和/或射线照相基准。例如，身体可以是具有通道的接口管体，该通道被配置为接收患者的牙齿，使得当患者咬在嘴件上时，接口管被重复且一致地放置在患者的相同相对位置。应答器可以是交替磁转发器，基准可以是金种子。其他实施例包括具有两件式主体的装置，具有可兴奋的应答器的本体的第一部分和具有放射照相基准的本体的第二部分。

3. 发明申请

WO2004060475A3 PANEL-TYPE SENSOR/SOURCE ARRAY ASSEMBLY 审中-公开
标题翻译：面板传感器/源阵列组件
公开(公告)号：WO2004060475A3
公开(公告)日：2007-07-26
申请号：PCT/US0341140
申请日：2003-12-23
申请人： CALYPSO MED TECHNOLOGIES INC , HERRON MATTHEW A , WHITE BRYAN , LEFORS JON H , TRUSLOW SAM
发明人： HERRON MATTHEW A , WHITE BRYAN , LEFORS JON H , TRUSLOW SAM
IPC分类号： A61B5/05 , A61B19/00 , A61N5/10
CPC分类号： A61N5/1049 , A61B2090/3958 , A61N5/1065 , A61N2005/1051 , Y10S128/922
摘要： A low-density sensor panel assembly system is provided for use with remote marker assemblies that generates a marker signal and for use with a radiation therapy source that generates a radiation beam during radiation therapy. The system includes a sensor array having a layer of sensor coils arrangedin a selected pattern and configured to receive the marker signal from the remote marker. A support panel is connected to the sensor array and retains each of the sensor coils in a substantially fixed and unmoving position relative to the other sensor coils. The sensor panel and sensor array define a low-density panel structure configured to dwell in the radiation beam during the radiation therapy.
摘要翻译：提供了一种低密度传感器面板组合系统，用于与产生标记信号的远程标记组件一起使用，并与用于在放射治疗期间产生辐射束的放射治疗源一起使用。该系统包括传感器阵列，该传感器阵列具有以选定图案排列的传感器线圈层，并且被配置为从远程标记接收标记信号。支撑面板连接到传感器阵列并且将每个传感器线圈相对于其它传感器线圈保持在基本上固定和不移动的位置。传感器面板和传感器阵列限定了一种低密度面板结构，其被配置为在辐射治疗期间驻留在辐射束中。

4. 发明申请

WO2005037167A2 PATIENT SUPPORT SYSTEMS FOR USE WITH RADIATION THERAPY SYSTEMS AND OTHER APPLICATIONS 审中-公开
标题翻译：患者支持系统使用辐射治疗系统和其他应用
公开(公告)号：WO2005037167A2
公开(公告)日：2005-04-28
申请号：PCT/US2004034523
申请日：2004-10-18
申请人： CALYPSO MED TECHNOLOGIES INC , DIMMER STEVEN C , HERRON MATTHEW A , VERTATSCHITSCH EDWARD J
发明人： DIMMER STEVEN C , HERRON MATTHEW A , VERTATSCHITSCH EDWARD J
IPC分类号： A61B5/06 , A61B6/04 , A61G20060101 , A61G
CPC分类号： A61B5/06 , A61B6/0442
摘要： An apparatus for supporting a patient in radiation therapy and other applications. In one embodiment, the apparatus includes a support structure and a panel carried by the support structure. The support structure can have first and second support members, such as rigid girders or other structures comprising substantially dielectric materials. The panel is also a rigid structure comprising substantially dielectric materials. The panel can further include a pass-through zone or other type of zone that is compatible with an ionizing radiation beam. For example, the panel can have a grid or solid low-density structure that mitigates beam contamination. The support structure and the panel together are configured to position a magnetic marker implanted in the patient in a navigational zone in which a magnetic field transmitted from the marker is not affected by conductive components or loops of conductive material in the pedestals or cantilevered support structures of conventional patient systems.
摘要翻译：一种用于在放射治疗和其他应用中支持患者的装置。在一个实施例中，该装置包括支撑结构和由支撑结构承载的面板。支撑结构可以具有第一和第二支撑构件，例如刚性梁或包括基本介电材料的其他结构。面板也是包括基本介电材料的刚性结构。面板还可以包括与电离辐射束相容的通过区域或其他类型的区域。例如，面板可以具有减轻束污染的网格或固体低密度结构。支撑结构和面板一起构造成将植入患者体内的磁性标记定位在导航区域中，其中从标记物传输的磁场不受基座或悬臂支撑结构中的导电材料的导电部件或环的影响常规患者系统。

5. 发明申请

WO2006012631A3 INTEGRATED RADIATION THERAPY SYSTEMS AND METHODS FOR TREATING A TARGET IN A PATIENT 审中-公开
标题翻译：集成辐射疗法系统和方法用于治疗患者的目标
公开(公告)号：WO2006012631A3
公开(公告)日：2006-07-13
申请号：PCT/US2005026447
申请日：2005-07-25
申请人： CALYPSO MED TECHNOLOGIES INC , MEIER ERIC , MATE TIMOTHY P , WRIGHT J NELSON , DIMMER STEVEN C , PURDY LYNN M
发明人： MEIER ERIC , MATE TIMOTHY P , WRIGHT J NELSON , DIMMER STEVEN C , PURDY LYNN M
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1051
摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.
摘要翻译：集成放射治疗过程包括通过使用定位模式周期性地定位位于患者体内的标记来获取与患者内的目标的参数相关的第一客观目标数据。该方法继续通过周期性地定位标记来获得与目标的参数相关的第二客观目标数据。第一客观目标数据可以在与第二区域分开的第一区域中获取，该第二区域包含用于产生用于治疗患者的电离辐射束的辐射输送装置。本地化模式在第一和第二方面可以是相同的。在其他实施例中，第一客观目标数据可以使用第一定位模式来获取，该第一定位模式使用第一能量类型来识别标记，并且第二客观目标数据可以使用第二定位模式来获得，该第二定位模式使用第二能量类型来识别标记与第一种能量类型不同。

6. 发明申请

WO2012045092A2 DELIVERY CATHETER FOR AND METHOD OF DELIVERING AN IMPLANT, FOR EXAMPLE, BRONCHOSCOPICALLY IMPLANTING A MARKER IN A LUNG 审中-公开
标题翻译：用于传送植入物的传送导管和方法，例如，在肺中布置标记的BRONCHOSCOPICALLY
公开(公告)号：WO2012045092A2
公开(公告)日：2012-04-05
申请号：PCT/US2011054656
申请日：2011-10-03
申请人： CALYPSO MED TECHNOLOGIES INC , QUIGLEY FERGUS
发明人： QUIGLEY FERGUS
IPC分类号： A61M25/092
CPC分类号： A61M25/00 , A61B1/2676 , A61B90/39 , A61B2017/00867 , A61B2034/2051 , A61B2090/3987 , A61B2090/3991 , A61M25/0105 , A61M25/0108 , A61M25/09 , A61M31/005 , A61M2025/09166 , A61N5/1049
摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.
摘要翻译：用于治疗患者肺部的系统和方法。一种方法的一个实施例包括将无引线标记物相对于靶标定位在患者的肺中，以及收集标记物的位置数据。该方法还包括基于所收集的位置数据确定标记在患者外部的外部参考框架中的位置，以及响应于标记的移动而在外部参考框架中提供客观输出。以导致临床上可接受的跟踪误差的频率（即，周期性）提供目标输出。此外，目标输出还可以至少基本同时提供，收集用于确定标记位置的位置数据。

7. 发明申请

WO2006020377A9 ANCHORING WIRELESS MARKERS WITHIN A HUMAN BODY 审中-公开
标题翻译：在人体内锚定无线标记
公开(公告)号：WO2006020377A9
公开(公告)日：2006-04-20
申请号：PCT/US2005026430
申请日：2005-07-25
申请人： CALYPSO MED TECHNOLOGIES INC , SEILER KEITH , HADFORD ERIC , PURDY LYNN M
发明人： SEILER KEITH , HADFORD ERIC , PURDY LYNN M
CPC分类号： A61B90/39 , A61B90/98 , A61B2090/3908
摘要： Apparatus and methods for anchoring implanted wireless markers in a patient's body to accurately locate a small target within a soft tissue region. One embodiment of the invention comprises a casing, a transponder partially encased in the casing, and an anchor protruding from the casing. The anchor can either be an extension of the casing or a separate component partly embedded in the casing. Different embodiments of the invention may be well suited for percutaneous implantation and/or surgical implantation.
摘要翻译：用于将植入的无线标记物锚定在患者体内以精确定位软组织区域内的小目标的设备和方法。本发明的一个实施例包括壳体，部分包封在壳体中的应答器以及从壳体突出的锚定件。锚可以是外壳的延伸部分或部分嵌入外壳中的单独部件。本发明的不同实施例可能非常适合于经皮植入和/或手术植入。

8. 发明申请

WO2006012630A3 APPARATUSES AND METHODS FOR PERCUTANEOUSLY IMPLANTING OBJECTS IN PATIENTS 审中-公开
标题翻译：用于佩戴佩戴在患者身上的物体的方法和方法
公开(公告)号：WO2006012630A3
公开(公告)日：2006-04-06
申请号：PCT/US2005026438
申请日：2005-07-25
申请人： CALYPSO MED TECHNOLOGIES INC , SEILER KEITH , HADFORD ERIC , GISSELBERG MARGO
发明人： SEILER KEITH , HADFORD ERIC , GISSELBERG MARGO
IPC分类号： A61M31/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B17/3478 , A61B2090/3987 , A61N5/1027 , A61N2005/1011
摘要： Apparatuses and methods for percutaneously implanting objects, such as radioactive seeds or markers, in patients. In one embodiment, a device (200) for percutaneously implanting an object in a patient includes a handle (210), a cannula (240) projecting outwardly from handle, and an actuator (23) movably disposed relative to the handle. In one aspect of this embodiment, the cannula can be configured to releasably hold the object and percutaneously penetrate the patient. In another aspect of this embodiment, the actuator can be operably connected to the cannula and operable to move the cannula relative to the handle and release the object within the patient. In a further aspect of this embodiment, the cannula can include a tip portion (242) having a restriction (243) configured to releasably hold the object for implantation in the patient.
摘要翻译：用于经皮植入物体（如放射性种子或标记物）的患者的装置和方法。在一个实施例中，用于经皮植入患者物体的装置（200）包括手柄（210），从手柄向外突出的插管（240）和相对于手柄可移动地设置的致动器（23）。在该实施例的一个方面中，插管可被配置为可释放地保持物体并经皮穿透患者体内。在该实施例的另一方面，致动器可以可操作地连接到套管并且可操作以相对于手柄移动插管并释放患者体内的物体。在该实施例的另一方面，套管可以包括具有限制（243）的末端部分（242），其被配置为可释放地将物体保持在患者体内。

9. 发明申请

WO2005067563A2 INSTRUMENTS WITH LOCATION MARKERS AND METHODS FOR TRACKING INSTRUMENTS THROUGH ANATOMICAL PASSAGEWAYS 审中-公开
标题翻译：具有位置标记的仪器和通过解剖学通过跟踪仪器的方法
公开(公告)号：WO2005067563A2
公开(公告)日：2005-07-28
申请号：PCT/US2005001525
申请日：2005-01-12
申请人： CALYPSO MED TECHNOLOGIES INC , WRIGHT J NELSON , DIMMER STEVEN C
发明人： WRIGHT J NELSON , DIMMER STEVEN C
IPC分类号： A61B5/05 , A61B5/06 , A61B19/00 , A61M25/01
CPC分类号： A61M25/0127 , A61B5/06 , A61B5/062 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2034/2072
摘要： Instruments and methods for tracking such instruments in a human patient. One embodiment of an instrument in accordance with the invention comprises an elongated body, such as an elongated flexible member, which has a distal section configured to be passed through a vessel or other passageway in a human. The instrument can further include a lumen through the distal section and a magnetic marker having a transponder at the distal section. The transponder includes a circuit configured to be energized by a wirelessly transmitted magnetic excitation energy and to wirelessly transmit a magnetic location signal in response to the excitation energy. The magnetic marker, for example, can be attached to or otherwise integral with the instrument.
摘要翻译：用于在人类患者中跟踪这些器械的仪器和方法。根据本发明的器械的一个实施例包括细长主体，例如细长的柔性构件，其具有构造成穿过人体中的血管或其它通道的远侧部分。仪器还可以包括通过远侧部分的内腔和在远侧部分具有应答器的磁性标记。应答器包括被配置为由无线传输的磁激发能量激励并且响应于激发能量无线地发送磁位置信号的电路。例如，磁性标记可以附着到仪器或以其他方式与仪器一体。

10. 发明申请

WO2004061460A3 IMPLANTABLE MARKER WITH A WIRELESS SIGNAL TRANSMITTER COMPATIBLE FOR USE IN MAGNETIC RESONANCE IMAGING DEVICES AND/OR SUITABLE FOR USE IN RADIATION IMAGING PROCESSES 审中-公开
标题翻译：具有无磁信号发射器的可移动标记，用于磁共振成像装置和/或适用于辐射成像过程中
公开(公告)号：WO2004061460A3
公开(公告)日：2005-07-07
申请号：PCT/US0341329
申请日：2003-12-24
申请人： CALYPSO MED TECHNOLOGIES INC , DIMMER STEVEN C , HADFORD ERIC
发明人： DIMMER STEVEN C , HADFORD ERIC
IPC分类号： A61B5/055 , A61B5/06 , A61B5/00 , A61B19/00
CPC分类号： A61B5/06 , A61B5/055 , A61B5/062 , A61B2090/3975 , Y10T29/43 , Y10T29/4902 , Y10T29/49073 , Y10T29/49194
摘要： A wireless (e.g., leadless) marker for localizing the position of a target within a patient. In one embodiment, the marker includes a casing, a resonating circuit, and a ferromagnetic element. The ferromagnetic element can have a volume such that when the marker is in an imaging magnetic field having a field strength of 1.5 T and a gradient of 3 T/m, then the force exerted on the marker by the imaging magnetic field is not greater than gravitational force exerted on the marker. In an alternative embodiment, the ferromagnetic element need not have such a volume, but the marker further includes an imaging element incorporated with the casing and/or the magnetic transponder (e.g., resonating circuit). The imaging element produces a radiographic profile in a radiographic image such that the marker has a radiographic centroid at least approximately coincident with the magnetic centroid of the transponder.
摘要翻译：用于定位患者内的目标位置的无线（例如，无引线）标记。在一个实施例中，标记包括壳体，谐振电路和铁磁元件。铁磁元件可以具有这样的体积，使得当标记处于场强为1.5T和3T / m的梯度的成像磁场中时，由成像磁场施加在标记上的力不大于施加在标记上的重力。在替代实施例中，铁磁元件不需要具有这样的体积，但是标记还包括与壳体和/或磁转发器（例如谐振电路）结合的成像元件。成像元件在放射照相图像中产生放射照相轮廓，使得标记具有与应答器的磁性质心至少近似一致的射线照相质心。

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