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1. 发明申请

US20150018301A1 LRRK-2-Mediated Neuronal Toxicity 审中-公开
标题翻译： LRRK-2介导的神经元毒性
公开(公告)号：US20150018301A1
公开(公告)日：2015-01-15
申请号：US13508180
申请日：2010-11-08
申请人： Byoung Dae Lee , Ted M. Dawson , Valina L. Dawson , Andrew B. West , Howard Federoff
发明人： Byoung Dae Lee , Ted M. Dawson , Valina L. Dawson , Andrew B. West , Howard Federoff
IPC分类号： A61K31/553 , A61K31/404 , A61K31/7064 , A61K31/122 , A61K31/416
CPC分类号： A61K31/553 , A61K31/122 , A61K31/403 , A61K31/404 , A61K31/416 , A61K31/519 , A61K31/7064
摘要： Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration were identified. The presently disclosed subject matter establishes that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for treating Parkinson's disease.
摘要翻译：亮氨酸重复激酶-2（LRRK2）突变是帕金森病的常见病因。鉴定了在LRRK2诱导的神经变性的体外和体内模型中保护的LRRK2激酶的抑制剂。目前公开的主题确定LRRK2诱导的体内神经元的变性是激酶依赖性的，并且LRRK2激酶抑制提供了治疗帕金森病的潜在的新的神经保护范例。

2. 发明授权

US06873169B1 Carrier module for semiconductor device test handler 失效
标题翻译：半导体器件测试处理器的载体模块
公开(公告)号：US06873169B1
公开(公告)日：2005-03-29
申请号：US10797072
申请日：2004-03-11
申请人： Chul Ho Ham , Byoung Dae Lee , Ho Keun Song , Young Geun Park
发明人： Chul Ho Ham , Byoung Dae Lee , Ho Keun Song , Young Geun Park
IPC分类号： G01R1/04 , G01R31/02
CPC分类号： G01R1/0433
摘要： Carrier module for a semiconductor device test handler including a carrier module body, a device seating part in an underside part of the carrier module body, at least one pair of first latches at opposite sides of the device seating part arranged opposite to, and movable away from, or close to, each other, for holding, or releasing opposite side parts of the semiconductor device seated on the device seating part, at least one pair of second latches rotatably fitted on opposite sides of the first latch, for holding an underside part of the semiconductor device seated on the device seating part, and releasing the semiconductor device interlocked with a releasing action of the first latch, a latch button fitted in an upper part of the carrier module to move in up/down directions and coupled to one end of the first latch, for moving up and down to make the first latch to move, and a first elastic member, and a second elastic member for elastic supporting of the first latch, and the second latch, thereby securely holding, transferring, and bringing the semiconductor device into contact with the test socket, for testing.
摘要翻译：一种用于半导体器件测试处理器的载体模块，包括载体模块主体，载体模块主体的下侧部分中的装置安置部分，在装置座部分的相对侧的至少一对第一闩锁，其布置成相对并移动从或彼此靠近，用于保持或释放位于设备安置部分上的半导体器件的相对侧部分，至少一对可旋转地安装在第一闩锁的相对侧上的第二闩锁，用于保持下侧部分并且释放与第一闩锁的释放动作互锁的半导体装置，安装在载体模块的上部中的闩锁按钮，以在上/下方向上移动并耦合到一端的第一闩锁，用于上下移动以使第一闩锁移动;以及第一弹性构件和用于弹性支撑第一闩锁的第二弹性构件，第二闩锁的第二弹性构件从而牢固地保持，传送和使半导体器件与测试插座接触以进行测试。

3. 发明授权

US07951779B2 Method of protecting cells against damage and pharmaceutical composition comprising leumorphin 有权
标题翻译：保护细胞免受损伤的方法和包含leumorphin的药物组合物
公开(公告)号：US07951779B2
公开(公告)日：2011-05-31
申请号：US11482480
申请日：2006-07-06
申请人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
发明人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
IPC分类号： A61K38/33
CPC分类号： A61K38/33
摘要： The present invention relates to a method of protecting cells against damage caused at least in part by apoptosis, comprising administering to subjects a therapeutic dose of leumorphin having cytoprotective activity, and a pharmaceutical composition comprising an effective amount of leumorphin having a cytoprotective activity.
摘要翻译：本发明涉及一种保护细胞免受至少部分通过细胞凋亡引起的损伤的方法，包括向受试者施用具有细胞保护活性的治疗剂量的亮氨酸，以及包含有效量的具有细胞保护活性的亮氨酸的药物组合物。

4. 发明申请

US20100120662A1 Glucose uptake modulator and method for treating diabetes or diabetic complications 审中-公开
标题翻译：葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法
公开(公告)号：US20100120662A1
公开(公告)日：2010-05-13
申请号：US12657083
申请日：2010-01-13
申请人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K38/28 , A61K31/661 , A61K38/16 , A61P3/10
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要翻译：本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂。

5. 发明申请

US20090312250A1 EPIDERMAL GROWTH FACTOR INCREASING INSULIN SECRETION AND LOWERING BLOOD GLUCOSE 审中-公开
标题翻译：生长因子增加胰岛素分泌和降低血糖
公开(公告)号：US20090312250A1
公开(公告)日：2009-12-17
申请号：US12373691
申请日：2007-07-16
申请人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
IPC分类号： A61K38/18
CPC分类号： A61K38/1808
摘要： The present inventors show that a brief exposure to EGF stimulates insulin secretion glucose-independently via a Ca2+ influx- and PLD2-dependent mechanism. Furthermore, the present invention shows that EGF is a novel secretagogue that lowers plasma glucose levels in normal and diabetic mice, suggesting the potential for EGF treatment in diabetes.
摘要翻译：本发明人表明，EGF的短暂暴露通过Ca2 +流入和PLD2依赖性机制独立地刺激胰岛素分泌葡萄糖。此外，本发明显示EGF是降低正常糖尿病小鼠血浆葡萄糖水平的新型促分泌素，表明在糖尿病中EGF治疗的潜力。

6. 发明授权

US06518745B2 Device test handler and method for operating the same 失效
公开(公告)号：US06518745B2
公开(公告)日：2003-02-11
申请号：US09805214
申请日：2001-03-14
申请人： Seong Bong Kim , Yang Hee Kim , Won Hee Jo , Byoung Dae Lee , Hyun Soo Oh
发明人： Seong Bong Kim , Yang Hee Kim , Won Hee Jo , Byoung Dae Lee , Hyun Soo Oh
IPC分类号： G01R3102
CPC分类号： G01R31/01
摘要： A device test handler and a method for operating the same provide a significant reduction of the picking up and placing time periods, and reduce possible damage to the devices being tested. Devices and methods embodying the invention facilitate room temperature and high temperature testing within one device test handler to maximize testing efficiency. A test handler embodying the invention may include a pre-heater for pre-heating the devices on a loading shuttle as the loading shuttle passes to a test chamber. An indexing device in a test chamber of the device is used for successively transferring the devices from a loading shuttle to the test socket, and tested devices from the test socket to an unloading shuttle. Heat supply means may be provided for supplying a high temperature heat to the test chamber when the devices are required to be tested in a hot state. An unloading part having a plurality of trays movably fitted on the base is used to transfer devices from an unloading shuttle to output trays based on the testing results.

7. 发明申请

US20100291089A1 LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE 审中-公开
标题翻译：调节免疫反应的配对及其在治疗免疫反应相关疾病中的应用
公开(公告)号：US20100291089A1
公开(公告)日：2010-11-18
申请号：US11993655
申请日：2006-07-07
申请人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K39/395 , C07K14/435 , A61K38/08 , A61K39/10 , A61K31/5377 , A61K31/352 , A61K31/713 , A61P37/02 , A61P29/00 , A61P25/28 , A61P9/10 , A61P35/00
CPC分类号： A61K38/1796 , A61K38/08
摘要： The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA).
摘要翻译：本发明涉及调节免疫应答的配体，即垂体腺苷酸环化酶活化多肽和血清淀粉样蛋白A（SAA）之一的PACAP27及其在治疗或预防与免疫应答有关的疾病中的新用途。更具体地，本发明涉及具有对免疫应答的调节作用的PACAP27-FPRL1的复合物及其在调节免疫应答中的用途。另一方面，本发明涉及SAA和FPRL1的复合物及其在抑制滑膜细胞增生和血管生成中的用途，并且治疗或预防包括类风湿性关节炎（RA）在内的炎性疾病。

8. 发明申请

US20080207490A1 Glucose Uptake Modulator and Method for Treating Diabetes or Diabetic Complications 审中-公开
标题翻译：葡萄糖摄取调节剂及治疗糖尿病并发症的方法
公开(公告)号：US20080207490A1
公开(公告)日：2008-08-28
申请号：US11994380
申请日：2006-07-07
申请人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K38/28 , C07F9/02 , C07K14/62 , A61K31/685 , A61P3/04 , C07K14/00 , A61K38/16
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要翻译：本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂。

9. 发明授权

US07061101B2 Carrier module 失效
标题翻译：运营商模块
公开(公告)号：US07061101B2
公开(公告)日：2006-06-13
申请号：US10797073
申请日：2004-03-11
申请人： Chul Ho Ham , Byoung Dae Lee , Ho Keun Song , Young Geun Park
发明人： Chul Ho Ham , Byoung Dae Lee , Ho Keun Song , Young Geun Park
IPC分类号： H01L29/74
CPC分类号： G01R31/2893
摘要： Carrier module including a carrier module body for seating a semiconductor device on an underside thereof, having a pass through hole from an upper part to the underside the semiconductor device is seated thereon, a housing over the carrier module body, a supplementary housing fitted in a lower part of the housing to be movable in up/down directions, for elastic contact with the carrier module body by a first elastic member fitted inside of the housing, a vacuum tube in the supplementary housing so as to be in communication with the pass through hole in the carrier module body, at least one pair of latches in a lower part of the carrier module body to move apart or close in an outer or inner side, for holding or releasing the semiconductor device seated on the carrier module body, a latch button fitted in an upper part of the carrier module body so as to be movable in up/down directions, and coupled to the latch with a connection pin for moving in up/down directions by an external force, to making the latch to move, and a second elastic member for elastic supporting of the latch buttons on the carrier module body, thereby, when the semiconductor device is brought into contact with the test socket, and tested, holding the semiconductor device with a vacuum formed through the pass through hole in the carrier module body and the vacuum tube in a state the latch releases the semiconductor device.
摘要翻译：载体模块包括用于将半导体器件放置在其下侧上的载体模块体，其具有从半部装置所在的上部到下侧的通孔，载体模块主体上的壳体，安装在其中的辅助壳体壳体的下部能够在上下方向上移动，通过安装在壳体内部的第一弹性构件与载体模块主体弹性接触，辅助壳体中的真空管与通孔连通载体模块主体中的至少一个闩锁，载体模块主体的下部中的至少一对闩锁，用于在外侧或内侧上分开或关闭，用于保持或释放位于载体模块主体上的半导体器件，闩锁按钮装配在载体模块主体的上部，以便能够在上/下方向上移动，并且通过一个连接销连接到闩锁上，该连接销通过一个外部的forc在上/下方向上移动 e，使闩锁移动;以及第二弹性构件，用于弹性地支撑载体模块主体上的闩锁按钮，由此当半导体器件与测试插座接触并进行测试时，将半导体器件保持在在闩锁释放半导体器件的状态下通过载体模块体中的通孔形成的真空和真空管。

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