专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4707497A Phenylethanolaminotetralines, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：苯乙醇氨基四氢化萘，其制备方法和含有它们的药物组合物
公开(公告)号：US4707497A
公开(公告)日：1987-11-17
申请号：US883961
申请日：1986-07-10
申请人： Roberto Cecchi , Robert Boigegrain , Alberto Bianchetti , Elena Poggesi , Tiziano Croci
发明人： Roberto Cecchi , Robert Boigegrain , Alberto Bianchetti , Elena Poggesi , Tiziano Croci
IPC分类号： A61K31/135 , A61K31/19 , A61K31/22 , A61P3/04 , C07C67/00 , C07C213/00 , C07C215/64 , C07C217/74 , C07C219/26 , A61K31/215 , C07C101/30
CPC分类号： A61K31/135
摘要： A novel phenylethanolaminotetraline having lipolytic activity of formula ##STR1## wherin X represents hydrogen, halogen, a trifluoromethyl or a lower alkyl group and R represents hydrogen, a lower alkyl group not substituted or substituted by a cycloalkyl group containing 3 to 7 carbon atoms, a hydroxy group, a lower alkoxy, carboxy or lower carbalkoxy group; a cycloalkyl group containing 3 to 7 carbon atoms; or a lower alcanoyl group; or a pharmaceutically acceptable salt thereof; a process for its preparation; and pharmaceutical compositions containing it as active ingredient, useful for the treatment of obesity.
摘要翻译：具有式（I）的脂肪分解活性的新型苯基乙醇氨基三氯乙酸表示氢，卤素，三氟甲基或低级烷基，R表示氢，未被取代或被含有3〜7个碳原子的环烷基取代的低级烷基，羟基，低级烷氧基，羧基或低级烷氧羰基; 含有3〜7个碳原子的环烷基; 或低级烷酰基; 或其药学上可接受的盐; 其准备过程; 和含有它作为活性成分的药物组合物，其可用于治疗肥胖症。

2. 发明授权

US4013679A Substituted 6,7-dihydro [1,7-ab](1) benzazepine compounds 失效
标题翻译：取代的6,7-二氢（1,7-AB）（1）苄基化合物
公开(公告)号：US4013679A
公开(公告)日：1977-03-22
申请号：US591763
申请日：1975-06-30
申请人： Mario Riva , Luciano Toscano , Giampiero Grisanti , Alberto Bianchetti
发明人： Mario Riva , Luciano Toscano , Giampiero Grisanti , Alberto Bianchetti
IPC分类号： C07D487/06
CPC分类号： C07D487/06
摘要： This invention relates to compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and include hydrogen, methyl, and benzyl, their method of preparation, and pharmaceutical compositions containing these compounds.

3. 发明授权

US5604245A Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a medicament for the treatment of conditions deriving from disorders of the serotoninergic systems mediated by 5-HT.sub.3 receptors 失效
标题翻译： 4-氨基-1-（2-吡啶基）哌啶用于制备用于治疗由5-HT 3受体介导的血清素能系统的病症的病症的药物的用途
公开(公告)号：US5604245A
公开(公告)日：1997-02-18
申请号：US858483
申请日：1992-03-27
申请人： G erard Le Fur , Alberto Bianchetti , Antonina Giudice , Tiziano Croci , Philippe Soubrie
发明人： G erard Le Fur , Alberto Bianchetti , Antonina Giudice , Tiziano Croci , Philippe Soubrie
IPC分类号： C07D401/04 , A61K31/44 , A61K31/4427 , A61K31/445 , A61P1/00 , A61P1/10 , A61P25/00 , A61P25/18 , A61P25/20 , A61P43/00
CPC分类号： A61K31/445 , A61K31/44
摘要： The present invention concerns the use of 4-amino-1-(2-pyridyl)piperidines of general formula (I') ##STR1## wherein R' represents hydrogen, a halogen atom, a methyl, methylthio, trifluoromethyl, trifluoromethylthio, (C.sub.1 -C.sub.3)alkoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, or phenoxy group optionally substituted with a halogen atom, a trifluoromethyl, (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, or cyano group, or of a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment or prophylaxis of those conditions deriving from disorders of the serotoninergic systems wherein a serotoninergic action selectively mediated by the 5-HT.sub.3 receptors is required, e.g. affective disorders, anxiety, psychotic troubles, constipation.
摘要翻译：本发明涉及通式（I'）卤素原子的4-氨基-1-（2-吡啶基）哌啶，甲基，甲硫基，三氟甲基，三氟甲硫基，（C 1 -C 3）烷氧基，三氟甲氧基，2,2 ，（C 3 -C 3）烷基，（C 1 -C 3）烷氧基，（C 1 -C 3）烷硫基或氰基，或其药学上可接受的盐，任选被卤素原子取代的2-三氟乙氧基或苯氧基，用于制备用于治疗或预防源自5-羟色胺能系统疾病的那些病症的药物，其中需要由5-HT 3受体选择性介导的血清素能作用，例如情感障碍，焦虑症，精神障碍，便秘。

4. 发明授权

US4691019A Anorectic agent; 4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine 失效
标题翻译：厌食剂 4-（3-三氟甲基苯基）-1-（2-氰基乙基）-1,2,3,6-四氢吡啶
公开(公告)号：US4691019A
公开(公告)日：1987-09-01
申请号：US811490
申请日：1985-12-20
申请人： Dino Nisato , Emilio Crisafulli , Alberto Bianchetti , Paolo Carminati
发明人： Dino Nisato , Emilio Crisafulli , Alberto Bianchetti , Paolo Carminati
IPC分类号： C07D211/70 , C07D211/68
CPC分类号： C07D211/70
摘要： The invention relates to 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to the salts thereof, having an anorectic acitivity, to a process for preparing same and to pharmaceutical compositions containing said compounds, useful in the treatment of obesity.
摘要翻译：本发明涉及式“IMAGE”的4-（3-三氟甲基苯基）-1,2,3,6-四氢吡啶，其中R表示3至7个碳原子的氰基，乙酰基或环烷基，Alk表示直链或具有1至4个碳原子的支链亚烷基，以及其具有厌食活性的盐，其制备方法和含有所述化合物的药物组合物，其可用于治疗肥胖症。

5. 发明授权

US4602024A Substituted trifluoromethylphenyltetrahydropyridines having a cyano substituent and an anorectic activity, a process for preparing same and pharmaceutical compositions 失效
标题翻译：具有氰基取代基和厌氧活性的取代的三氟甲基苯基四氢吡啶，其制备方法和药物组合物
公开(公告)号：US4602024A
公开(公告)日：1986-07-22
申请号：US630969
申请日：1984-07-16
申请人： Dino Nisato , Emilio Crisafulli , Alberto Bianchetti , Paolo Carminati
发明人： Dino Nisato , Emilio Crisafulli , Alberto Bianchetti , Paolo Carminati
IPC分类号： A61K31/445 , A61K31/451 , A61P3/04 , C07D211/70 , A61K31/44
CPC分类号： C07D211/70 , Y10S514/91
摘要： The invention relates to 4-(-3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to the salts thereof, having an anorectic activity, to a process for preparing same and to pharmaceutical compositions containing said compounds, useful in the treatment of obesity.
摘要翻译：本发明涉及式（IMAGE）的4-（ - 3-三氟甲基苯基）-1,2,3,6-四氢吡啶，其中R表示3至7个碳原子的氰基，乙酰基或环烷基，Alk表示直链或具有1至4个碳原子的支链亚烷基，以及其具有厌食活性的盐，其制备方法和含有所述化合物的药物组合物，其可用于治疗肥胖症。

6. 发明授权

US4439444A Amidobenzamides, their salts and pharmaceutical compositions containing them 失效
标题翻译：二苯甲酰胺，其盐和含有它们的药物组合物
公开(公告)号：US4439444A
公开(公告)日：1984-03-27
申请号：US396100
申请日：1982-07-07
申请人： Dino Nisato , Sergio Boveri , Alberto Bianchetti , Romeo Roncucci , Paolo Carminati
发明人： Dino Nisato , Sergio Boveri , Alberto Bianchetti , Romeo Roncucci , Paolo Carminati
IPC分类号： C07D307/52 , C07D405/12 , C07D409/12 , A61K31/34 , C07D307/54
CPC分类号： C07D405/12 , C07D307/52 , C07D409/12 , Y10S514/926 , Y10S514/927
摘要： Amidobenzamides acting as histamine H.sub.2 receptors blocking agents, of formula ##STR1## wherein A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl-1-oxyde, pyrazinyl or thienyl; their salts; process for their preparation by reaching 2-(5-dimethyl-aminomethylfuran-2-ylmethylthio)ethylamine with a derivative of formula ##STR2## and optional salification and pharmaceutical compositions containing same.
摘要翻译：苯甲酰胺作为组胺H 2受体阻断剂，其中A是CO或SO 2，B是烷基，苯基，吡啶基，吡啶基-1-氧代，吡嗪基或噻吩基; 他们的盐通过得到具有式“IMAGE”的衍生物的2-（5-二甲基 - 氨基甲基呋喃-2-基甲硫基）乙胺和含有其的任选的成盐和药物组合物来制备它们的方法。

7. 发明授权

US5973006A Fluoro-substituted benzoylpropionic acid derivatives 失效
标题翻译：氟取代的苯甲酰基丙酸衍生物
公开(公告)号：US5973006A
公开(公告)日：1999-10-26
申请号：US51486
申请日：1998-04-20
申请人： Mario Varasi , Antonio Giordani , Carmela Speciale , Massimo Cini , Alberto Bianchetti
发明人： Mario Varasi , Antonio Giordani , Carmela Speciale , Massimo Cini , Alberto Bianchetti
IPC分类号： A61K31/00 , A61K31/165 , A61K31/195 , A61K31/197 , A61K31/22 , A61P5/36 , A61P25/08 , A61P25/16 , A61P25/28 , C07C227/12 , C07C229/36 , C07C237/20 , C07C259/06 , A01N37/12 , A01N37/18 , C07C229/28 , C07C233/05
CPC分类号： C07C259/06 , C07C229/36 , C07C237/20
摘要： A fluoro-substituted benzoylpropionic acid compound of formula (I) either as a single optical isomer or as a mixture of optical isomers ##STR1## wherein R is hydroxy, amino, hydroxylamine, --OR', --NHR', N(R').sub.2 or --NHOR' in which R' is C.sub.1 -C.sub.6 alkyl or benzyl;or a pharmaceutically acceptable salt thereof.
摘要翻译： PCT No.PCT / EP96 / 04321 Sec。 371日期：1998年4月20日 102（e）1998年4月20日PCT PCT 1996年10月4日PCT公布。第WO97 / 15550号公报日期：1997年5月1日一种式（I）的氟取代的苯甲酰基丙酸化合物作为单一光学异构体或作为光学异构体的混合物，其中R是羟基，氨基，羟胺，-OR'，-NHR'，N（R' ）2或-NHOR'，其中R'是C 1 -C 6烷基或苄基; 或其药学上可接受的盐。

8. 发明授权

US5026716A Method of treatment of anxiety and anxio-depressive disorders 失效
标题翻译：焦虑和焦虑抑郁症治疗方法
公开(公告)号：US5026716A
公开(公告)日：1991-06-25
申请号：US437674
申请日：1989-11-17
申请人： Alberto Bianchetti , Gerard Le Fur , Jacques Simiand , Philippe Soubrie
发明人： Alberto Bianchetti , Gerard Le Fur , Jacques Simiand , Philippe Soubrie
IPC分类号： C07D211/70 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/451 , A61P25/20 , C07D401/06 , A01N43/40 , C07D499/46
CPC分类号： A61K31/44
摘要： A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine derivative of formula I ##STR1## wherein Alk represents a straight or branched (C.sub.1 -C.sub.4)alkylene chain and R is selected from the group consisting of cyano, acetyl, (C.sub.3 -C.sub.7)cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
摘要翻译：描述了一种治疗哺乳动物焦虑和抑郁症的方法，其包括向有需要的哺乳动物施用有效量的式I的三氟甲基苯基 - 四氢吡啶衍生物其中Alk表示直链或支链（C1-C4）亚烷基链和R选自氰基，乙酰基，（C 3 -C 7）环烷基，吡啶基，1-氧化物 - 吡啶基和萘基，或其药学上可接受的盐。

9. 发明授权

US5002946A Phenylethanolamine analog active compounds for the treatment of gastrointestinal diseases 失效
标题翻译：苯乙醇胺类似物活性化合物用于治疗胃肠道疾病
公开(公告)号：US5002946A
公开(公告)日：1991-03-26
申请号：US501302
申请日：1990-03-23
申请人： Luciano Manara , Tiziano Croci , Alberto Bianchetti
发明人： Luciano Manara , Tiziano Croci , Alberto Bianchetti
IPC分类号： A61K31/165 , A61K31/135 , A61K31/195 , A61K31/235 , A61K31/34 , A61K31/343 , A61K31/395 , A61P1/00 , A61P1/12 , C07D295/04 , C07D295/18 , C07D307/80
CPC分类号： A61K31/34 , A61K31/135
摘要： Phenylethanolamine analog active compounds, optionally substituted on the phenyl group with an halogen atom or with an alkyl or trifluoromethyl group and substituted on the amino group with a phenylalkyl or phenoxy alkyl group optionally substituted on the benzene ring, are used for the treatment and/or prophylaxis of gastrointestinal diseases associated with a smooth muscle contraction.
摘要翻译：苯基乙醇胺类似物活性化合物，任选在苯基上被卤素原子或与烷基或三氟甲基取代并且在氨基上被苯环烷基或苯环烷基任意取代在苯环上取代，用于处理和/或预防与平滑肌收缩相关的胃肠道疾病。

10. 发明授权

US5786508A Substituted kynurenines and process for their preparation 失效
标题翻译：替代的犬尿苷及其制备方法
公开(公告)号：US5786508A
公开(公告)日：1998-07-28
申请号：US411656
申请日：1995-04-06
申请人： Robert Schwarcz , Mario Varasi , Arturo Della Torre , Carmela Speciale , Alberto Bianchetti
发明人： Robert Schwarcz , Mario Varasi , Arturo Della Torre , Carmela Speciale , Alberto Bianchetti
IPC分类号： C07C229/36 , A61K31/195 , C07C239/36
CPC分类号： C07C229/36 , C07C2101/14
摘要： The present invention relates to the use in the treatment of cognitive disorders associated with the aging processes of the brain and perinatal brain disorders of compounds which act as inhibitors of the enzyme kynurenine aminotransferase (KAT). The present invention also provides, as novel compounds, a selected class of KAT inhibitors which are the compounds of formula (IA) ##STR1## wherein R is halogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.6 -C.sub.10 aryloxy, phenyl-C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, and R.sub.1 is hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, mono-C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino, hydroxylamino, C.sub.1 -C.sub.4 alkoxyamino or benzyloxyamino, with the provisos that: (i) when R.sub.1 is hydroxy and, at the same time, R is halogen, then this halogen is not fluorine; and (ii) when R.sub.1 is hydroxy and, at the same time, R is C.sub.1 -C.sub.6 alkyl, then this C.sub.1 -C.sub.6 alkyl is not methyl, either as a single isomer or as a mixture of isomers, and the pharmaceutically acceptable salts thereof.
摘要翻译： PCT No.PCT / US94 / 07804 Sec。 371日期：1995年4月6日 102（e）日期1995年4月6日PCT 1994年7月15日PCT公布。公开号WO95 / 04714 日期1995年2月16日本发明涉及用作治疗与作为犬尿氨酸转氨酶（KAT）酶抑制剂的化合物的脑老化过程和围产期脑疾病相关的认知障碍的用途。本发明还提供作为新化合物的选择类别的作为式（IA）化合物的KAT抑制剂，其中R是卤素，C 1 -C 6烷基，C 5 -C 7环烷基，苯基-C 1 -C 4烷基， C 1 -C 6烷氧基，C 6 -C 10芳氧基，苯基-C 1 -C 4烷氧基或三氟甲基，R 1是羟基，C 1 -C 6烷氧基，氨基，单-C 1 -C 6烷基氨基，二-C 1 -C 6烷基氨基，羟基氨基，C 1 -C 4 烷氧基氨基或苄氧基氨基，条件是：（ⅰ）当R 1为羟基，同时R为卤素时，该卤素不为氟; 和（ii）当R 1是羟基，并且同时R是C 1 -C 6烷基时，则该C 1 -C 6烷基不是甲基，作为单一异构体或作为异构体的混合物，以及其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式