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1. 发明申请

WO2013039958A1 ANTIBODIES TO PCSK9 AND USES THEREOF 审中-公开
标题翻译： PCSK9的抗体及其用途
公开(公告)号：WO2013039958A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054737
申请日：2012-09-12
申请人： ELI LILLY AND COMPANY , DAVIES, Julian , ALLAN, Barrett , DARLING, Ryan James
发明人： DAVIES, Julian , ALLAN, Barrett , DARLING, Ryan James
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9), or antigen-binding fragments thereof, compositions comprising such PCSK9 antibodies or antigen-binding fragments, and methods of using the same for the treatment of hyperlipidemia or hypercholesterolemia.
摘要翻译：本发明涉及抗蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）抗体或其抗原结合片段，包含该PCSK9抗体或抗原结合片段的组合物，及其用于治疗高脂血症或高胆固醇血症的方法。

2. 发明申请

WO2007070750A1 ANTI-IL-17 ANTIBODIES 审中-公开
标题翻译：抗IL-17抗体
公开(公告)号：WO2007070750A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/061586
申请日：2006-12-05
申请人： ELI LILLY AND COMPANY , ALLAN, Barrett , CHOW, Chi-kin , HUANG, Lihua , LIU, Ling , LU, Jirong , NG, Kingman , TETREAULT, Jonathan, Wendell , WERNER, Andrew, Gordon
发明人： ALLAN, Barrett , CHOW, Chi-kin , HUANG, Lihua , LIU, Ling , LU, Jirong , NG, Kingman , TETREAULT, Jonathan, Wendell , WERNER, Andrew, Gordon
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen- binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders.
摘要翻译：鉴定出抗IL-17抗体的特征在于对人IL-17具有高亲和力和缓慢的速率。本发明的抗体可以是嵌合，人源化或完全人抗体，抗体的免疫缀合物或其抗原结合片段。本发明的抗体特别用于治疗自身免疫性，炎症性，细胞增殖性和发育性疾病。

3. 发明申请

WO2006020114A3 VARIANT FC REGIONS 审中-公开
标题翻译：不同的FC地区
公开(公告)号：WO2006020114A3
公开(公告)日：2006-04-06
申请号：PCT/US2005025276
申请日：2005-07-18
申请人： APPLIED MOLECULAR EVOLUTION , ALLAN BARRETT , JIANG WEIDONG , TANG YING , WATKINS JEFFRY DEAN
发明人： ALLAN BARRETT , JIANG WEIDONG , TANG YING , WATKINS JEFFRY DEAN
IPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , C12N5/10 , C12N15/12
CPC分类号： C07K16/2887 , C07K16/2896 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptides, particularly therapeutic antibodies, comprising a novel, variant Fc region. Furthermore the invention provides variant Fc regions which confer an altered effector function or altered serum half life upon a polypeptide to which it is operable attached.
摘要翻译：本发明提供了多肽，特别是治疗性抗体，其包含新的变体Fc区。此外，本发明提供变体Fc区，其赋予其可操作连接的多肽上改变的效应子功能或改变的血清半衰期。

4. 发明申请

WO2004074455A2 Fc REGION VARIANTS 审中-公开
标题翻译： Fc区域变量
公开(公告)号：WO2004074455A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005112
申请日：2004-02-20
申请人： APPLIED MOLECULAR EVOLUTION , WATKINS, Jeffry, D. , ALLAN, Barrett
发明人： WATKINS, Jeffry, D. , ALLAN, Barrett
IPC分类号： C12N
CPC分类号： A61K39/395 , A61K2039/505 , C07K16/00 , C07K16/2896 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
摘要翻译：本发明提供多肽Fc区变体和编码Fc区变体的寡核苷酸。具体地，本发明提供包含新型Fc区变体的组合物，用于鉴定有用的Fc区变体的方法，以及使用Fc区变体用于治疗疾病的方法。

5. 发明申请

WO2006020114A2 VARIANT FC REGIONS 审中-公开
标题翻译： VARIANT FC地区
公开(公告)号：WO2006020114A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025276
申请日：2005-07-18
申请人： APPLIED MOLECULAR EVOLUTION, INC. , ALLAN, Barrett , JIANG, Weidong , TANG, Ying , WATKINS, Jeffry, Dean
发明人： ALLAN, Barrett , JIANG, Weidong , TANG, Ying , WATKINS, Jeffry, Dean
IPC分类号： C07K16/00
CPC分类号： C07K16/2887 , C07K16/2896 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptides, particularly therapeutic antibodies, comprising a novel, variant Fc region. Furthermore the invention provides variant Fc regions which confer an altered effector function or altered serum half life upon a polypeptide to which it is operable attached.
摘要翻译：本发明提供了包含新的变体Fc区的多肽，特别是治疗性抗体。此外，本发明提供了赋予改变的效应子功能或改变其可操作地连接的多肽上的血清半衰期的变体Fc区。

6. 发明申请

WO2004074455A3 Fc REGION VARIANTS 审中-公开
标题翻译： Fc区域变量
公开(公告)号：WO2004074455A3
公开(公告)日：2005-02-17
申请号：PCT/US2004005112
申请日：2004-02-20
申请人： APPLIED MOLECULAR EVOLUTION , WATKINS JEFFRY D , ALLAN BARRETT
发明人： WATKINS JEFFRY D , ALLAN BARRETT
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： A61K39/395 , A61K2039/505 , C07K16/00 , C07K16/2896 , C07K2317/21 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
摘要翻译：本发明提供多肽Fc区变体和编码Fc区变体的寡核苷酸。具体地，本发明提供包含新型Fc区变体的组合物，用于鉴定有用的Fc区变体的方法，以及使用Fc区变体用于治疗疾病的方法。

7. 发明申请

WO2004103404A1 CD20 BINDING MOLECULES 审中-公开
标题翻译： CD20结合分子
公开(公告)号：WO2004103404A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015786
申请日：2004-05-20
申请人： APPLIED MOLECULAR EVOLUTION , WATKINS, Jeffry, D. , DAVIES, Julian , MARQUIS, David, M. , ALLAN, Barrett, W. , ONDEK, Brian
发明人： WATKINS, Jeffry, D. , DAVIES, Julian , MARQUIS, David, M. , ALLAN, Barrett, W. , ONDEK, Brian
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
摘要翻译：本发明涉及CD20结合分子和编码CD20结合分子的核酸序列。特别地，本发明涉及关于人CD20具有高结合亲和力和低解离速率的CD20结合分子。优选地，本发明的CD20结合分子包含具有完全人骨架（例如人种系框架）的轻链和/或重链可变区。

8. 发明申请

WO2011156324A1 CGRP ANTIBODIES 审中-公开
标题翻译： CGRP抗体
公开(公告)号：WO2011156324A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/039381
申请日：2011-06-07
申请人： ELI LILLY AND COMPANY , ALLAN, Barrett , BENSCHOP, Robert Jan , CHAMBERS, Mark Geoffrey , DARLING, Ryan James
发明人： ALLAN, Barrett , BENSCHOP, Robert Jan , CHAMBERS, Mark Geoffrey , DARLING, Ryan James
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/54 , C07K16/26 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides human engineered calcitonin gene related peptide (CGRP) antibodies or antigen-binding fragment thereof. In addition, the present invention provides the use of the human engineered calcitonin gene related peptide (CGRP) antibodies or antigen-binding fragment thereof for the treatment of osteoarthritis pain.
摘要翻译：本发明提供人工程降钙素基因相关肽（CGRP）抗体或其抗原结合片段。此外，本发明提供了人工程降钙素基因相关肽（CGRP）抗体或其抗原结合片段用于治疗骨关节炎疼痛的用途。

9. 发明申请

WO2005070963A1 FC REGION VARIANTS 审中-公开
标题翻译： FC区域变量
公开(公告)号：WO2005070963A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/000013
申请日：2005-01-10
申请人： APPLIED MOLECULAR EVOLUTION, INC , ALLAN, Barrett, W. , MARQUIS, David, Matthew , TANG, Ying , WATKINS, Jeffry, Dean
发明人： ALLAN, Barrett, W. , MARQUIS, David, Matthew , TANG, Ying , WATKINS, Jeffry, Dean
IPC分类号： C07K16/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
摘要翻译：本发明提供多肽Fc区变体和编码Fc区变体的寡核苷酸。具体地，本发明提供包含新型Fc区变体的组合物，用于鉴定有用的Fc区变体的方法，以及使用Fc区变体用于治疗疾病的方法。

10. 发明申请

WO2002072891A1 FLUORESCENCE ASSAY FOR DNA MODIFYING ENZYMES 审中-公开
标题翻译： DNA修饰酶的荧光测定
公开(公告)号：WO2002072891A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007413
申请日：2002-03-11
申请人： UNIVERSITY OF CALIFORNIA , REICH, Norbert, O. , ALLAN, Barrett, W. , LINDSTROM, William, Jr. , PUNTZKE, Aaron, P.
发明人： REICH, Norbert, O. , ALLAN, Barrett, W. , LINDSTROM, William, Jr. , PUNTZKE, Aaron, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/107
摘要： A method of assaying compounds for their ability to effect enzymes including enhancing or inhibiting the effect of those enzymes on double stranded DNA sequences is disclosed. The method comprises providing a modified nucleotide sequence comprised of a base analogue which analogue is characterized by increased fluorescence when moved out of its normal helical position, the sequence having a complimentary sequence hybridized thereto to provide a double stranded sequence. The modified sequence containing the base analogue is brought into contact with the enzyme which enzyme is characterized by effecting the 3-dimensional position of the analogue within the sequence. The enzyme is brought into contact with the sequences in the presence of a compound being assayed. By knowing the amount of increased fluorescence the enzyme would normally have on the sequence is possible to determine the inhibitory or enhancing effect of the compound on the enzyme.
摘要翻译：公开了一种测定化合物其影响酶的能力的方法，包括增强或抑制这些酶对双链DNA序列的影响。所述方法包括提供由碱基类似物组成的修饰的核苷酸序列，所述碱基类似物的特征在于当其从其正常螺旋位置移出时增加荧光，所述序列具有与其杂交的互补序列以提供双链序列。使含有碱基类似物的修饰的序列与该酶的酶接触，酶的特征在于在序列内实现类似物的3维位置。在待测化合物存在下使酶与序列接触。通过了解酶通常对该序列具有的荧光增加的量可以确定化合物对酶的抑制或增强的作用。

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