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1. 发明公开

EP0786011A1 A MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF 17BETA-CARBOXY SUBSTITUTED 3-OXO-4-AZASTEROIDS AND THE USE OF SUCH PRODUCTS AS INHIBITORS OF THE ENZYME 5ALPHA-REDUCTASE 失效转让
标题翻译：作为制作17β-羧基-3-氧代-4- azasteroids而且这些产品作为酶5-α还原酶抑制剂的使用微生物法
公开(公告)号：EP0786011A1
公开(公告)日：1997-07-30
申请号：EP95935926.0
申请日：1995-10-10
申请人： POLI INDUSTRIA CHIMICA S.p.A.
发明人： POLI, Stefano , MAGNI, Ambrogio , GRISENTI, Paride , LEONI, Massimo
IPC分类号： A61P5 , C07J73 , C12P33
CPC分类号： C07J73/005 , C12P33/02
摘要： The present invention relates to a microbiological process for the transformation of 17β-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5α-reductase.

2. 发明公开

EP0783521A1 POLYPEPTIDE COMPOUNDS CONTAINING D-2-ALKYLTRYPTOPHAN CAPABLE OF PROMOTING THE RELEASE OF GROWTH HORMONE 失效
标题翻译： D-2-alkylTryptophan含有生长激素释放活性的多肽
公开(公告)号：EP0783521A1
公开(公告)日：1997-07-16
申请号：EP95932735.0
申请日：1995-09-13
申请人： DEGHENGHI, Romano
发明人： DEGHENGHI, Romano
IPC分类号： A61K38 , A61P5 , C07K5 , C07K7 , C07K14
CPC分类号： C07K5/1013 , A61K38/00 , C07K5/0205 , C07K5/1024 , C07K14/60
摘要： A peptide of the formula: A-D-Mrp-(Ala)n-B-C wherein A is any natural L-amino acid or its D-isomer with the proviso that A is not His if B is Trp and C is D-Phe-Lys-NH2; or A is imidazoleacetyl, isonipecotyl, 4-aminobutyryl, 4-(aminomethyl)cyclohexanecarbonyl, Glu-Tyr-Ala-His, Tyr-Ala-His, Tyr-His, D-Thr-His; D relates to the dextro isomer, Mrp is 2-alkyltryptophan; n is 0 or 1; B is L- or D-Trp, Phe or D-β-naphthylalanine, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys-NH2, Phe-Lys-NH2, D-Phe-Lys-ThrNH2, D-Phe-Lys-D-ThrNH2, OR, wherein R is a C1-C3 alkyl group, and the addition salts with pharmaceutically acceptable organic or inorganic acids of anyone of said polypeptides, these compounds are capable of promoting the release of growth hormone, and are active by the oral route.

3. 发明公开

EP0670846A1 A PROCESS FOR THE PURIFICATION OF NATURAL PULMONARY SURFACTANT MATERIAL USING SUPERCRITICAL FLUIDS 失效
标题翻译：用于清洁肺天然表面活性剂BY超临界流体。
公开(公告)号：EP0670846A1
公开(公告)日：1995-09-13
申请号：EP94901823.0
申请日：1993-11-19
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： CHIESI, Paolo , VENTURA, Paolo , PIGHI, Roberto , SERVADIO, Vittorino , RECCHIA, Walter
IPC分类号： B01D11 , C07K14
CPC分类号： C07K14/785 , B01D11/0203 , Y02P20/544
摘要： Natural pulmonary surfactant material, consisting of a mixture of phospholipids and a small percentage of specific proteins, is purified by means of supercritical fluids, particularly with CO2.

4. 发明公开

EP0527896A1 SUBSTRATES AND INHIBITORS FOR PRENYL CYSTEINE METHYLTRANSFERASE ENZYMES 失效
标题翻译：底物和抑制剂用于PRENYLCYSTEIN甲基转移酶。
公开(公告)号：EP0527896A1
公开(公告)日：1993-02-24
申请号：EP91909734.0
申请日：1991-05-03
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： STOCK, Jeffry, B.
IPC分类号： C07C323 , C12Q1
CPC分类号： C12Q1/48 , C07C323/59
摘要： Composés de la formule (I), dans laquelle: R1 représente alkyle contenant 1 à 3 atomes de carbone; R2 représente -COX, dans lequel X représente hydroxy, méthyle, amino, thio, HN-(alkyle contenant 1 à 3 atomes de carbone), N-(alkyle contenant 1 à 3 atomes de carbone)2 ou halogène; R3 représente un alkyle à chaîne droite ou ramifiée contenant 10 à 25 atomes de carbone, ou un alcène à chaîne droite ou ramifiée, ou un alcène à chaîne droite ou ramifiée comprenant des alcènes poly-insaturés contenant 10 à 25 atomes de carbone; et le métal alcalin, le métal alcalino-terreux, l'ammonium, et ses sels d'ammonium substitués constituent spécifiquement, lorsque R2 représente -COOH, des substrats et/ou des inhibiteurs d'enzymes de méthyltransférase de cystéine de prényle, lesquelles catalysent le transfert de méthyle de S-adénosylméthionine aux C-terminaisons de protéines et de peptides présentant des résidus de cystéine prénylée au niveau de leurs C-terminaisons. Les composés, en tant que substrats, sont particulièrement adaptés à une utilisation dans des analyses permettant de détecter qualitativement ou quantitativement les enzymes de méthyltransférase de cystéine de farnésyle.

5. 发明公开

EP0833644A1 PHARMACEUTICAL AND DIET FORMULATIONS FOR THE PROPHYLAXIS AND TREATMENT OF GASTROINTESTINAL DISORDERS 失效
标题翻译：组合物，其肠道菌种，并包含谷氨酰胺
公开(公告)号：EP0833644A1
公开(公告)日：1998-04-08
申请号：EP96922842.0
申请日：1996-06-19
申请人： BRACCO S.p.A. , DIBRA S.p.A.
发明人： DE HAEN, Christoph , GOZZINI, Luigia
IPC分类号： A61K47 , A61K31 , A61K35 , A61K36 , A61K38 , A61P1
CPC分类号： A61K35/744 , A23L33/135 , A23L33/175 , A23L33/18 , A23V2002/00 , A61K35/747 , A23V2200/3202 , A23V2250/062
摘要： The present invention refers to pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders.

6. 发明公开

EP0782562A1 PROCESS FOR THE MANUFACTURING OF IODINATED CONTRAST AGENTS 有权
标题翻译：用于生产含碘造影剂
公开(公告)号：EP0782562A1
公开(公告)日：1997-07-09
申请号：EP96927036.0
申请日：1996-07-17
申请人： BRACCO S.p.A. , DIBRA S.p.A.
发明人： ANELLI, Pier, Lucio , BROCCHETTA, Marino , GAZZOTTI, Ornella , UGGERI, Fulvio
IPC分类号： C07C231 , C07C235 , C07C237
CPC分类号： C07C231/12 , C07C235/48 , C07C237/46
摘要： A process for the preparation of compounds of general formula (I) characterized in that the corresponding derivatives of general formula (II) are reacted with the compounds of general formula (III).

7. 发明公开

EP0773924A1 PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE 有权转让
标题翻译：用于生产二羧酸
公开(公告)号：EP0773924A1
公开(公告)日：1997-05-21
申请号：EP96916098.0
申请日：1996-05-17
申请人： Fructamine S.P.A.
发明人： MAURO, Marina , VISCARDI, Carlo, Felice , GAGNA, Massimo
IPC分类号： C07C313 , C07C227 , C07C229 , C07C381
CPC分类号： C07C227/18 , C07C381/10
摘要： The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride, comprising the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride, in a solvent selected from the group consisting of: (C7-C16) linear or branched hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butylacetate, diglyme (diethyleneglycoldimethylether), and in the presence of a catalytic amount of a tertiary amine.

8. 发明公开

EP0701604A1 IMMORTALIZATION OF DENDITRIC CELLS WITH V-MYC ONCOGENE 失效
标题翻译：名垂千古树突状细胞V-myc基因
公开(公告)号：EP0701604A1
公开(公告)日：1996-03-20
申请号：EP94917670.0
申请日：1994-05-26
申请人： BIOTOP S.A.S. DI RITA CASSARIN
发明人： GRANUCCI, Francesca
IPC分类号： C12N15 , A61K35 , A61K39 , C12N5
CPC分类号： C12N5/0639 , C12N2510/04
摘要： The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in antigen specific way.

9. 发明公开

EP0641329A1 COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY 失效
标题翻译：用血管紧张素II拮抗作用的链接。
公开(公告)号：EP0641329A1
公开(公告)日：1995-03-08
申请号：EP92916506.0
申请日：1992-08-03
申请人： ISTITUTO LUSO FARMACO D'ITALIA S.p.A.
发明人： SALIMBENI, Aldo , POMA, Davide , MANGHISI, Elso , SCOLASTICO, Carlo
IPC分类号： A61K31 , A61P5 , A61P9 , A61P13 , A61P15 , A61P27 , A61P43 , C07D239 , C07D403 , C07D405 , C07D409
CPC分类号： C07D239/26 , C07D239/34 , C07D239/36 , C07D239/47 , C07D239/54 , C07D403/10 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I), wherein R, R1, R2, R3, X and Z groups have the meanings given in the specification and are endowed with AII antagonistic properties.

10. 发明公开

EP0639978A1 PHARMACEUTICAL COMBINATION HAVING ANTINEOPLASTIC ACTIVITY 失效
标题翻译：与抗肿瘤活性的药物混合物。
公开(公告)号：EP0639978A1
公开(公告)日：1995-03-01
申请号：EP92910125.0
申请日：1992-05-12
申请人： ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
发明人： ESPOSITO, Mauro
IPC分类号： A61K33
CPC分类号： A61K33/24 , A61K31/165 , A61K2300/00
摘要： A pharmaceutical combination having antineoplastic activity based on platinum complexes and procainamide is described. Said combination shows a prolonged and remarkable activity, also in terms of survival and allows to obtain a remarkable protection against the typical platinum complex toxicity. Said combination can be both in the form suitable for the contemporaneous administration of the two components through parenteral or intracavitary route, and in the form of a kit containing two distinct pharmaceutical compositions, to be separately administered optionally through two different administration routes.

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