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1. 发明授权

US11951227B2 Nanofiber structures and methods of use thereof 有权
公开(公告)号：US11951227B2
公开(公告)日：2024-04-09
申请号：US17712601
申请日：2022-04-04
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： Jingwei Xie , Shixuan Chen , Mark Carlson
IPC分类号： A61L24/04 , A61K9/70 , A61L24/00 , A61L24/10 , A61L27/18 , A61L27/22 , A61L27/34 , A61L27/52 , A61L27/54 , D01D5/00 , D06M11/01 , D06M101/32 , D06N3/00
CPC分类号： A61L24/046 , A61K9/7007 , A61L24/0015 , A61L24/0031 , A61L24/104 , A61L27/18 , A61L27/222 , A61L27/34 , A61L27/52 , A61L27/54 , D01D5/0007 , D06M11/01 , A61L2300/404 , A61L2300/414 , A61L2300/418 , A61L2400/04 , A61L2400/12 , D06M2101/32 , D06N3/0004 , D06N2203/026 , D06N2203/028 , D06N2203/041 , D10B2509/022 , A61L24/046 , C08L67/04
摘要： Coated and expanded, nanofiber structures are provided and methods of use thereof.

2. 发明授权

US11851479B2 Methods and compositions for pertussis diagnosis 有权
公开(公告)号：US11851479B2
公开(公告)日：2023-12-26
申请号：US17058446
申请日：2019-06-18
申请人： DX DISCOVERY INC.
发明人： Amanda Burnham-Marusich
IPC分类号： C07K16/12 , G01N33/569 , G01N33/543 , A61K39/00
CPC分类号： C07K16/1225 , G01N33/54388 , G01N33/56911 , A61K2039/505 , C07K2317/565 , G01N2333/235
摘要： Compositions and methods for the detection and diagnosis of Bordetella pertussis are disclosed. Provided are antibodies, or antigen binding fragment thereof, specific for tracheal colonization factor A (TcfA). Also provided are compositions comprising an anti-TcfA antibody of the instant invention and a carrier; and methods for inhibiting, treating, and/or preventing pertussis and/or a B. pertussis infection in a subject in need thereof are provided, comprising administering an anti-TcfA antibody of the instant invention to the subject.

3. 发明授权

US11773510B2 Method of discovering specific functional antibodies 有权
公开(公告)号：US11773510B2
公开(公告)日：2023-10-03
申请号：US16064264
申请日：2017-05-24
申请人： GENEWIZ SUZHOU
发明人： Weizhi Chen , Xin Wu , Wang Wang , Zhongping Sun , Guojuan Liao
IPC分类号： C40B30/04 , C40B40/08 , C07K16/18 , C07K16/00 , C12N15/10 , C07K16/10 , G16B15/00 , G16C20/60 , G16B35/00 , C40B50/06
CPC分类号： C40B40/08 , C07K16/005 , C07K16/1018 , C07K16/1081 , C07K16/18 , C12N15/10 , C12N15/1062 , C12N15/1089 , C12N15/1096 , G16B15/00 , C07K2317/10 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B30/04 , C40B50/06 , G16B35/00 , G16C20/60
摘要： The invention relates to a method for discovering specific functional antibodies, in particular to a method for discovering specific functional antibodies based on sequence composition and frequency analysis of variable regions of immune host antibodies. Compared with conventional high-throughput antibody sequencing method, this method can quickly and accurately obtain the full-length sequence of the variable region of antibody containing candidate CDR3, the success rate of antibody gene pairing is high and it is suitable for the detection of few samples, and improves the efficiency of obtaining specific functional antibodies.

4. 外观设计

USD999624S1 Clamping members 有权
公开(公告)号：USD999624S1
公开(公告)日：2023-09-26
申请号：US29745707
申请日：2020-08-07
申请人： STREAMLIGHT, INC.
设计人： Raymond L. Sharrah , William D. Worman
摘要： FIG. 1 is a perspective view of an ornamental design of clamping members;
FIG. 2 is a perspective view thereof in the environment of a light;
FIG. 3 is a perspective view thereof from an opposite side than FIG. 1;
FIG. 4 is a view of a first side of the clamping members;
FIG. 5 is a view of a first of the respective ends thereof;
FIG. 6 is a view of second respective ends thereof;
FIG. 7 is a view of a third side thereof; and
FIG. 8 is a view of a fourth side thereof.
FIG. 9 is a perspective view of an ornamental design of clamping members;
FIG. 10 is a perspective view thereof in the environment of a light;
FIG. 11 is a perspective view thereof from an opposite side than FIG. 9;
FIG. 12 is a view of a first side of the clamping members;
FIG. 13 is a view of a first of the respective ends thereof;
FIG. 14 is a view of second respective ends thereof;
FIG. 15 is a view of a third side thereof; and,
FIG. 16 is a view of a fourth side thereof.
Broken lines in the DRAWING indicate parts of the article that are not claimed herein or indicate environment in FIGS. 2 and 10 that is not claimed herein, and that form no part of the claimed design.

5. 发明授权

US11745844B2 Aircraft and systems therefor 有权
公开(公告)号：US11745844B2
公开(公告)日：2023-09-05
申请号：US17609275
申请日：2020-05-07
申请人： Hybrid Air Vehicles Limited
发明人： Michael Durham , Paul Macey
IPC分类号： B64B1/62 , B64B1/40 , G01F17/00
CPC分类号： B64B1/62 , B64B1/40 , G01F17/00
摘要： A non-rigid airship or hybrid air vehicle has a pressure-stabilised envelope (100) that includes at least one ballonet (102, 103). A system is provided for measuring the geometry of the lifting gas enclosure (101) within the pressure-stabilised envelope (100). The system comprises a plurality of sensors (104, 109) located outside the ballonet(s) but inside the envelope, for measuring the geometry of the enclosure. Some of the sensors (104) are arranged to measure an internal surface of the pressure-stabilised envelope (100), and others of the sensors (109) are arranged to measure an external surface of the at least one ballonet (102, 103).

6. 发明授权

US11702684B2 Method for measuring protein and nucleic acid with ultrahigh sensitivity 有权
公开(公告)号：US11702684B2
公开(公告)日：2023-07-18
申请号：US16089488
申请日：2017-03-07
申请人： BioPhenoMA Inc
发明人： Etsuro Ito , Toshiaki Miura , Teruki Yoshimura , Satoshi Watabe
IPC分类号： C12Q1/32 , C12Q1/00 , G01N21/78 , G01N33/569 , G01N33/58 , G01N33/53 , G01N33/535 , C12Q1/68 , G01N21/25
CPC分类号： C12Q1/32 , C12Q1/008 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/535 , G01N33/5695 , G01N33/581 , G01N21/25 , G01N2333/35 , G01N2333/90209
摘要： The present invention pertains to an enzymatic measurement method using an antibody-enzyme complex or a nucleic acid probe measurement method using an enzyme-labeled nucleic acid probe, in both of which the quantification of a product of a reaction by an enzyme in the antibody-enzyme complex or the enzyme-labeled nucleic acid probe is performed by generating thio-NAD(P)H by an enzymatic cycling reaction using NAD(P)H, thio-NAD(P), and a dehydrogenase (DH), and measuring the amount of the generated thio-NAD(P)H or measuring a change in color caused by the generated thio-NAD(P)H. An enzymatic reaction system in which NAD(P) generated from NAD(P)H by the enzymatic cycling reaction is selectively reduced, is caused to coexist with the enzymatic cycling reaction. The present invention also pertains to a kit for enzyme immunoassay, and a kit for nucleic acid probe measurement. In the enzymatic cycling reaction, the detection sensitivity is increased by increasing the amount of thio-NAD(P)H generated per unit time with respect to a predetermined amount of a substrate (reduced), and combining the same with an enzyme immunoassay, etc., enables quantification, etc., of a protein or nucleic acid with high sensitivity.

7. 发明授权

US11607464B2 Compositions and methods for the treatment and imaging of cancer 有权
公开(公告)号：US11607464B2
公开(公告)日：2023-03-21
申请号：US16967527
申请日：2019-04-04
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： Janina Baranowska-Kortylewicz , Zbigniew Kortylewicz
IPC分类号： A61K51/04 , A61P35/00 , A61K31/4184 , A61B6/03 , A61N5/10 , C07D235/32
摘要： Compositions and methods for treating, detecting, and diagnosing cancer are disclosed.

8. 发明授权

US11553816B2 Device for preparing infusions 有权
公开(公告)号：US11553816B2
公开(公告)日：2023-01-17
申请号：US16494534
申请日：2017-08-02
申请人： INNOVATION CRAFT COMPANY, S.L.
发明人： Miguel Osorio Sánchez , Héctor Poyatos Rodas
IPC分类号： A47J31/54 , A23F5/26 , A47J31/06 , A47J36/02
摘要： The invention describes a device for preparing infüsions, suitable for preparing infüsions in a micro wave. The device comprises: a lowertank transparent to electromagnetic radiation, with a valve; an upper tank screwed to the lower tank; a funnel that connects the tanks; an extraction área containing material to be extracted with filtering means; a cover; and means for making the device leak tight, the device comprising áreas for shielding against electromagnetic waves in the extraction área, the upper tank and the cover. In the preferred embodiments, the device comprises a float, needles and thermal reinforcement áreas. The device allows infüsions to be obtained without the volatile compounds degrading.

9. 发明授权

US11525832B2 Protein signature/markers for the detection of adenocarcinoma 有权
公开(公告)号：US11525832B2
公开(公告)日：2022-12-13
申请号：US16578768
申请日：2019-09-23
申请人： IMMUNOVIA AB
发明人： Carl Arne Krister Borrebaeck , Lars Bertil Christer Wingren
IPC分类号： G01N33/574
摘要： The present invention provides a method for determining the presence of pancreatic adenocarcinoma in an individual and/or for determining the survival time of an individual afflicted with pancreatic adenocarcinoma comprising the steps of: (a) providing a serum or plasma sample to be tested; and (b) determining a protein signature of the test sample by measuring the presence and/or amount in the test sample of one or more selected proteins; wherein the presence and/or amount in the test sample of one or more proteins selected from the group defined in Table 1 is indicative of the presence of pancreatic adenocarcinoma. The invention also provides an array and a kit suitable for use in the methods of the invention.

10. 发明授权

US11473084B2 Compositions and methods for treating Huntington's disease and related disorders 有权
公开(公告)号：US11473084B2
公开(公告)日：2022-10-18
申请号：US15766549
申请日：2016-10-11
申请人： The Children's Hospital of Philadelphia
发明人： Beverly L. Davidson , Alejandro Mas Monteys , Shauna Ebanks
IPC分类号： C12N15/113 , C12N15/861 , C12N15/88 , C12N15/66 , C12N15/10 , A61K48/00 , A61P25/00 , C12N9/22
摘要： Compositions and methods are provided for the inhibition, treatment and/or prevention of Huntington's disease and related disorders.

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