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1. 发明专利

DE69629291D1 未知
公开(公告)号：DE69629291D1
公开(公告)日：2003-09-04
申请号：DE69629291
申请日：1996-05-24
申请人： IGEN INTERNATIONAL INC N D GES , MOSBACH KLAUS H , MAYES ANDREW G
发明人： MOSBACH KLAUS , MAYES G
IPC分类号： B01D15/38 , C07B57/00 , C08F2/00 , C08F2/20 , C08F2/44 , C08F220/28 , C08F220/30 , C08F220/38 , C08F290/06 , C08L33/14
摘要： The claimed invention is directed to a molecularly imprinted support formed from at least two distinct acylic monomers and at least one imprinted molecule. The support comprises beads having a uniform surface for reproducible presentation thereon.

2. 发明专利

DE69629291T2 未知
公开(公告)号：DE69629291T2
公开(公告)日：2004-04-22
申请号：DE69629291
申请日：1996-05-24
申请人： IGEN INTERNATIONAL INC N D GES , MOSBACH KLAUS H , MAYES ANDREW G
发明人： MOSBACH KLAUS , MAYES G
IPC分类号： B01D15/38 , C07B57/00 , C08F2/00 , C08F2/20 , C08F2/44 , C08F220/28 , C08F220/30 , C08F220/38 , C08F290/06 , C08L33/14
摘要： The claimed invention is directed to a molecularly imprinted support formed from at least two distinct acylic monomers and at least one imprinted molecule. The support comprises beads having a uniform surface for reproducible presentation thereon.

3. 发明申请

WO2004003504A2 IMPROVED ASSAY SYSTEMS AND COMPONENTS 审中-公开
标题翻译：改进的测试系统和组件
公开(公告)号：WO2004003504A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/019722
申请日：2003-06-20
申请人： IGEN INTERNATIONAL, INC.
发明人： DAVIS, Charles, Quentin , COOK, Richard, A.
IPC分类号： G01N
CPC分类号： B01L3/0293 , B01L3/021 , B01L9/523 , B01L2200/025 , B01L2200/143 , B01L2400/0478 , B01L2400/0622 , B01L2400/0633 , F04B53/06 , F04B53/16 , F04B53/162 , G01N35/028 , G01N35/1011 , G01N2035/042 , G01N2035/0437 , G01N2035/1018 , G01N2035/1025
摘要： Assay systems and components, and methods of using same. The assay system preferably includes one or more of the following components: I) an apparatus for retaining/positioning an assay plate; ii) a device for detecting proper alignment of an assay plate; iii) an apparatus for training a probe to locate and aspirate reagents and/or one or more samples; iv) a fluid handling device aspirating reagents; v) an apparatus for detecting the presence/absence of a reagent comprising a fluid handling manifold having both a transparent light path and a fluid conduit defined therein and vi) a positive displacement pump having a pump chamber improved to contain one or more of: bypass means; cleanout means; and/or gas and sediment removal means.
摘要翻译：测定系统和组件，以及使用方法。测定系统优选地包括一个或多个以下组分：I）用于保持/定位测定板的设备; ii）用于检测测定板的正确对准的装置; iii）用于训练探针以定位和吸出试剂和/或一种或多种样品的装置; iv）抽吸试剂的流体处理装置; v）用于检测试剂的存在/不存在的装置，其包括具有限定在其中的透明光路和流体导管的流体处理歧管，以及vi）正位移泵，其具有改进以容纳以下中的一个或多个的泵送室：旁路手段; 清理手段; 和/或气体和沉淀物去除装置。

4. 发明申请

WO2002034933A3 METHODS AND COMPOSITIONS FOR MODIFYING BIOLOGICALLY ACTIVE TARGET MOLECULES 审中-公开
公开(公告)号：WO2002034933A3
公开(公告)日：2002-05-02
申请号：PCT/US2001/031663
申请日：2001-10-10
申请人： IGEN INTERNATIONAL, INC.
发明人： MARTIN, Mark, T.
IPC分类号： A61K38/43
摘要： The present invention provides a method of modifying a target substance by contacting the target substance with a catalyst that catalyzes the modification of the target substance. In a preferred embodiment, the method comprises labeling a target substance by contacting the target substance with a label and a catalyst that catalyzes the attachment of the label to the target substance. Preferably, the catalyst catalyses selectively the reaction between a specific target molecule and a specific label. The attachment of labels may be used to inactivate a biologically active target substance or otherwise modulate its activity. Alternatively, the method may be used to label the target molecule with a detectable label suitable for the sensitive detection of the target substance.

5. 发明申请

WO2004001380A2 ELECTROCHEMILUMINESCENCE FLOW CELL AND FLOW CELL COMPONENTS 审中-公开
标题翻译：电致发光细胞和流动细胞成分
公开(公告)号：WO2004001380A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/019691
申请日：2003-06-19
申请人： IGEN INTERNATIONAL, INC
发明人： KUMAR, Sudeep, M. , OTTEN, Josephus Marinus , DAVIS, Charles Quentin , BIEBUYCK, Hans
IPC分类号： G01N
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, irridium or an alloy of platinum, rhodium or irridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more fiel extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由与包含过渡元素的合金材料合金化的铑，铱或铂，铑或铱合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个延伸元件。场延伸元件优选地是梯子或栅格。

6. 发明申请

WO2004073615A2 DEAZAFLAVIN COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译： DEAZAFLAVIN化合物及其使用方法
公开(公告)号：WO2004073615A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/004130
申请日：2004-02-12
申请人： THE UNITED STATES OF AMERICA represented by THESE SECRETARY, THE DEPARTMENT OF HEALTH & HUMAN SERVICES , IGEN INTERNATIONAL, INC. , WEISSMAN, Allan, M. , VOUSDEN, Karen, H. , JENSEN, Jane, P. , YANG, Yili , FANG, Shengyun , WOODS, Douglas, , KENTEN, John, H. , DAVYDOV, Llia , SAFIRAN, Yassamin, J. , OBEROI, Pankaj
发明人： WEISSMAN, Allan, M. , VOUSDEN, Karen, H. , JENSEN, Jane, P. , YANG, Yili , FANG, Shengyun , WOODS, Douglas, , KENTEN, John, H. , DAVYDOV, Llia , SAFIRAN, Yassamin, J. , OBEROI, Pankaj
IPC分类号： A61K
CPC分类号： C07D471/04
摘要： The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
摘要翻译：本发明的特征在于5-脱氮黄素化合物，5-脱氮黄素化合物的药物组合物和治疗患有癌症的患者的方法，所述方法包括给予患者一种或多种本发明的5-脱氮嘌呤化合物。

7. 发明申请

WO2004003219A2 IMPROVED ASSAY SYSTEMS AND COMPONENTS 审中-公开
标题翻译：改进的测试系统和组件
公开(公告)号：WO2004003219A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/019690
申请日：2003-06-19
申请人： IGEN INTERNATIONAL, INC.
发明人： DAVIS, Charles, Quentin , COOK, Richard, A.
IPC分类号： C12Q
CPC分类号： B01L3/0293 , B01L3/021 , B01L9/523 , B01L2200/025 , B01L2200/143 , B01L2400/0478 , B01L2400/0622 , B01L2400/0633 , F04B53/06 , F04B53/16 , F04B53/162 , G01N35/028 , G01N35/1011 , G01N2035/042 , G01N2035/0437 , G01N2035/1018 , G01N2035/1025
摘要： Assay systems and components, and methods of using same. The assay system preferably includes one or more of the following components: i) an apparatus for retaining/positioning an assay plate; ii) a device for detecting proper alignment of an assay plate; iii) an apparatus for training a probe to locate and aspirate reagents and/or one or more samples; iv) a fluid handling device for aspirating reagents; v) an apparatus for detecting the presence/absence of a reagent comprising a fluid handling manifold having both a transparent light path and a fluid conduit defined therein and vi) a positive displacement pump having a pump chamber improved to contain one or more of: bypass means; cleanout means; and/or gas and sediment removal means.
摘要翻译：测定系统和组件，以及使用方法。测定系统优选地包括以下组件中的一种或多种：i）用于保持/定位测定板的设备; ii）用于检测测定板的正确对准的装置; iii）用于训练探针以定位和吸出试剂和/或一种或多种样品的装置; iv）用于抽吸试剂的流体处理装置; v）用于检测试剂的存在/不存在的装置，其包括具有限定在其中的透明光路和流体导管的流体处理歧管，以及vi）正位移泵，其具有改进以容纳以下中的一个或多个的泵送室：旁路手段; 清理手段; 和/或气体和沉淀物去除装置。

8. 发明申请

WO2003002974A2 ECL LABELS HAVING IMPROVED NON-SPECIFIC BINDING PROPERTIES, METHODS OF USING AND KITS CONTAINING THE SAME 审中-公开
标题翻译：具有改进的非特异性结合特性的ECL标签，使用方法和包含其的工具
公开(公告)号：WO2003002974A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/019788
申请日：2002-06-21
申请人： IGEN INTERNATIONAL, INC.
发明人： SIGAL, George, B. , TJIONG, Howie , DONG, Liwen , MASOOD, Athar , TITMAS, Richard, C.
IPC分类号： G01N
CPC分类号： C07D213/30 , C07D213/34 , C07D213/40 , C07D213/81 , C07D471/04 , C07F9/582 , C07F9/6561 , C07F15/0053 , C09B57/00 , C09B57/10 , G01N33/582 , G01N2458/40
摘要： Bipyridine or phenanthroline ligands presenting functional groups that prevent non-specific binding (in particular, negatively charged functional groups that are unaffected by standard conditions for conjugating biological reagents through amide bonds) are described as are luminescent metal complexes comprising these ligands. The use of luminescent ruthenium and osmium complexes comprising these ligands in electrochemiluminescence assays shows that the use of these labels can significantly reduce the amount of non-specific binding observed relative to assays carried out using reagents labeled with analogous labels that don't present functional groups that decrease non-specific binding.
摘要翻译：描述了呈现阻止非特异性结合的官能团的联吡啶或菲咯啉配体（特别是不受标准条件影响的通过酰胺键缀合生物试剂的带负电荷的官能团）描述为包含这些配体的发光金属络合物。在电化学发光测定中使用包含这些配体的发光钌和锇络合物显示，使用这些标记物的使用可以显着减少相对于使用不具有官能团的类似标记标记的试剂进行的测定而观察到的非特异性结合的量这降低了非特异性结合。

9. 发明申请

WO1997032886A1 ECL LABELS HAVING IMPROVED NSB PROPERTIES 审中-公开
标题翻译：具有改进NSB特性的ECL标签
公开(公告)号：WO1997032886A1
公开(公告)日：1997-09-12
申请号：PCT/US1997004150
申请日：1997-03-06
申请人： IGEN INTERNATIONAL, INC.
发明人： IGEN INTERNATIONAL, INC. , LELAND, Jonathan, K. , GUDIBANDE, Satyanarayana, R. , SHEN, Lihong
IPC分类号： C07F15/00
CPC分类号： G01N33/533
摘要： The present invention is directed to modified electrochemiluminescent compounds and to associated processes for performing assays using these compounds wherein, in comparison to their corresponding unmodified counterparts, these compounds have decreased nonspecific binding properties.
摘要翻译：本发明涉及修饰的电化学发光化合物和用于使用这些化合物进行测定的相关方法，其中与其相应的未修饰对应物相比，这些化合物具有降低的非特异性结合性质。

10. 发明申请

WO1997028275A1 ELECTROCHEMILUMINESCENCE ENZYME ASSAY 审中-公开
标题翻译：电子荧光测定
公开(公告)号：WO1997028275A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001916
申请日：1997-02-05
申请人： IGEN INTERNATIONAL, INC. , MARTIN, Mark, T. , DONG, Liwen
发明人： IGEN INTERNATIONAL, INC.
IPC分类号： C12Q01/34
CPC分类号： C12Q1/34 , C12Q2334/00 , Y10S435/817 , Y10S435/968 , Y10S435/975
摘要： A rapid single step assay suitable for the detection or quantification of enzymes, in particular, hydrolases, such as aminopeptidases and esterases is described. The enzymatic reaction causes the cleavage of a metal ligand labeled hydrolase substrate. The cleavec ligand alters the electrochemiluminescence of bidentate aromatic heterocyclic nitrogen-containing ligand reagent. The change in electrochemiluminescence correlates to the presence of hydrolase activity present in the sample. The assay can be performed on an IGEN Origen Analyzer. The figure illustrates ECL detection of mixtures of ruthenium (II) tris(bipyridyl) and various concentrations of either picolinic acid (1) (black bars) or 2-pyridinecarboxylic acid ethyl ester (4) (white bars).
摘要翻译：描述了适用于检测或定量酶，特别是水解酶如氨基肽酶和酯酶的快速单步测定法。酶反应导致金属配体标记的水解酶底物的裂解。裂解配体改变二齿芳族杂环含氮配体试剂的电化学发光。电化学发光的变化与样品中存在的水解酶活性的存在相关。该测定可以在IGEN Origen分析仪上进行。该图示出了钌（II）三（联吡啶）和各种浓度的吡啶甲酸（1）（黑条）或2-吡啶羧酸乙酯（4）（白色条）的混合物的ECL检测。

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