发明专利
ZA200202517B Amino Substituted Pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-Triazines.
未知
基本信息:
- 专利标题： Amino Substituted Pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-Triazines.
- 申请号：ZA200202517 申请日：2002-03-28
- 公开(公告)号：ZA200202517B 公开(公告)日：2003-05-28
- 发明人： STEPHANE DARROW JAMES W DE LOM , BLUM CHARLES , DAVI TRAN JENNIFER GIANGIORDAN , ALBERT CARPINO PHILIP
- 申请人： NEUROGEN CORP PFIZER INC
- 专利权人： NEUROGEN CORP PFIZER INC
- 当前专利权人： NEUROGEN CORP PFIZER INC
- 优先权： US15686899 1999-09-30
- 主分类号： A61K31/155
- IPC分类号： A61K31/155 ; A61K31/427 ; A61K31/519 ; A61K31/53 ; G01N33/50 ; A61K31/64 ; A61K31/7034 ; A61K38/28 ; A61K45/00 ; A61P1/12 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P7/04 ; A61P9/00 ; A61P9/04 ; A61P9/12 ; A61P11/02 ; A61P15/00 ; A61P25/00 ; A61P25/04 ; A61P25/06 ; A61P25/08 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; A61P43/00 ; C07D487/04 ; G01N33/15 ; G01N33/566 ; A61K ; A61P ; C07D ; G01N
摘要：
Disclosed are compounds of the formula:where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided.Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/155 | ..脒NCN，例如胍（H2N—C（NH）—NH2）、异脲（HNC（OH）NH2），异硫脲 |