基本信息:
- 专利标题： STRUCTURES FOR REDUCING ANTIBODY-LIPASE BINDING
- 申请号：PCT/US2022/073526 申请日：2022-07-08
- 公开(公告)号：WO2023288182A1 公开(公告)日：2023-01-19
- 发明人： HECHT, Elizabeth Sara , MEHTA, Shrenik Chetan , SANDOVAL, Wendy Noel , ALAVATTAM, Sreedhara , TZIZIK-SWANSON, Nathaniel Robert
- 申请人： GENENTECH, INC.
- 申请人地址： 1 DNA Way
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： 1 DNA Way
- 代理机构： DOHERTY, Elizabeth A. et al.
- 优先权： US63/220,894 2021-07-12
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12N9/20
摘要：
The present application relates to recombinant antibodies that are engineered to alter interactions between the antibodies and one or more endogenous lipases of a host cell used to produce the antibodies. In some cases, the antibodies are mutated in the heavy chain constant region, such as at CH1, CH2, and/or CH3. In other cases, the antibodies are mutated to alter their glycosylation profile.