发明申请
WO2023060083A1 COMPOSITIONS, SYSTEMS, AND METHODS RELATING TO THREE-DIMENSIONAL (3D) BIOPRINTED LIVER TISSUE MODELS
审中-公开
基本信息:
- 专利标题： COMPOSITIONS, SYSTEMS, AND METHODS RELATING TO THREE-DIMENSIONAL (3D) BIOPRINTED LIVER TISSUE MODELS
- 申请号：PCT/US2022/077536 申请日：2022-10-04
- 公开(公告)号：WO2023060083A1 公开(公告)日：2023-04-13
- 发明人： ANGELINI, Thomas Ettor , ABRAHAN, Carolina Elizabeth , CHISOLM, Steven , DOBSON, Jon P. , MATHEWS, Clayton Elwood , MCFETRIDGE, Peter S. , PALMER, Glyn Daniel , SUBRAMANIAM, Vignesh , SUMERLIN, Brent S. , BAUDY, Andreas , HIGGINS, Brett
- 申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
- 申请人地址： 223 Grinter Hall
- 专利权人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
- 当前专利权人地址： 223 Grinter Hall
- 代理机构： THOMAS HORSTEMEYER LLP
- 优先权： US63/252,334 2021-10-05
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; B33Y80/00 ; B33Y70/00 ; C12N2501/12 ; C12N2502/14 ; C12N2502/28 ; C12N2503/02 ; C12N2533/54 ; C12N2535/10 ; C12N5/067 ; C12N5/069 ; C12N5/0697
摘要：
Disclosed herein are compositions, systems, and methods relating to three-dimensional bioprinted tissue models, in particular liver tissue modes. Compositions, systems, and methods as described here provide for improved tissue models, thereby improving their utility for diagnostic, clinical, and research purposes. In certain aspects, tissue models as described herein exhibit gene expression profiles, enzymatic function, and enzyme/protein secretion comparable to in vivo organs.