发明申请
WO2023049328A2 ELECTROCHEMICAL APTAMER SENSORS WITH STABLE BLOCKING LAYERS, RAPID ELECTRON TRANSFER AND ROBUST ANTIFOULING PROPERTIES
审中-公开
基本信息:
- 专利标题： ELECTROCHEMICAL APTAMER SENSORS WITH STABLE BLOCKING LAYERS, RAPID ELECTRON TRANSFER AND ROBUST ANTIFOULING PROPERTIES
- 申请号：PCT/US2022/044512 申请日：2022-09-23
- 公开(公告)号：WO2023049328A2 公开(公告)日：2023-03-30
- 发明人： HEIKENFELD, Jason Charles
- 申请人： UNIVERSITY OF CINCINNATI
- 申请人地址： 2900 Reading Road
- 专利权人： UNIVERSITY OF CINCINNATI
- 当前专利权人： UNIVERSITY OF CINCINNATI
- 当前专利权人地址： 2900 Reading Road
- 代理机构： JEFFERIES, David E.
- 优先权： US63/248,016 2021-09-24
- 主分类号： G01N27/327
- IPC分类号： G01N27/327 ; C12Q1/26 ; G01N27/26
摘要：
The present invention relates to a device for continuous sensing of at least one analyte in a test fluid that is resistant at least one of desorption of a first plurality of molecules, including a plurality of aptamers and a blocking layer, and fouling during use of the device when exposed to temperatures greater than or equal to 30°C for at least 3 days. Another aspect of the invention is a method of providing fouling resistance to an aptamer sensor device wherein the blocking layer and aptamer are resistant to at least one of desorption from the electrode and fouling during use of the aptamer sensor when exposed to temperatures greater than or equal to 30°C for at least 3 days.
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N27/00 | 用电、电化学或磁的方法测试或分析材料 |
| --------G01N27/02 | .通过测试阻抗 |
| ----------G01N27/28 | ..电解池部件 |
| ------------G01N27/30 | ...电极，例如测试电极；半电池 |
| --------------G01N27/327 | ....生物化学电极 |