基本信息:
- 专利标题： GPX4 INHIBITORS AND USES THEREOF
- 申请号：PCT/US2022/076179 申请日：2022-09-09
- 公开(公告)号：WO2023039510A1 公开(公告)日：2023-03-16
- 发明人： STOCKWELL, Brent R. , LIU, Hengrui , FOROUHAR, Farhad , XIA, Xin , LIN, Annie , WANG, Qian
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： 412 Low Memorial Library
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： 412 Low Memorial Library
- 代理机构： YANG, Ke
- 优先权： US63/242,829 2021-09-10
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; C07D209/08
摘要：
The present disclosure provides, inter alia, compounds to modulate GPX4 activity. Also provided are pharmaceutical compositions containing same compounds. Further provided are methods for treating or ameliorating the effects of a cancer in a subject, methods of modulating GPX activity in a subject, methods of inducing ferroptosis in a cell, and methods for treating or ameliorating the effects of a cancer in a subject using the compounds or composition in combination with other therapeutic agents.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/403 | ....与碳环稠合的，例如咔唑 |
| ----------------A61K31/404 | .....吲哚类，例如吲哚洛尔 |