基本信息:
- 专利标题： iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
- 申请号：PCT/US2022/039242 申请日：2022-08-03
- 公开(公告)号：WO2023014765A1 公开(公告)日：2023-02-09
- 发明人： NIOI, Paul , MCININCH, James, D. , SCHLEGEL, Mark, K. , CASTORENO, Adam , BARRY, Joseph
- 申请人： ALNYLAM PHARMACEUTICALS, INC.
- 申请人地址： 675 West Kendall Street
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： 675 West Kendall Street
- 代理机构： ZACHARAKIS, Maria, Laccotripe et al.
- 优先权： US63/229,085 2021-08-04
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting an angiotensinogen (AGT) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of an AGT gene and to methods of preventing and treating an AGT- associated disorder, e.g., hypertension.