基本信息:
- 专利标题： SELF-CLEAVING POLYPROTEINS AND USES THEREOF
- 申请号：PCT/AU2022/050844 申请日：2022-08-04
- 公开(公告)号：WO2023010177A1 公开(公告)日：2023-02-09
- 发明人： TORRESI, Joseph
- 申请人： THE UNIVERSITY OF MELBOURNE
- 申请人地址： Grattan Street
- 专利权人： THE UNIVERSITY OF MELBOURNE
- 当前专利权人： THE UNIVERSITY OF MELBOURNE
- 当前专利权人地址： Grattan Street
- 代理机构： DAVIES COLLISON CAVE PTY LTD
- 优先权： AU2021902408 2021-08-04
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/12 ; A61K39/145 ; A61K39/215 ; A61K39/29 ; A61P31/12 ; C12N7/00 ; C07K14/005 ; C07K14/18
摘要：
Disclosed herein are vaccine constructs for producing a virus-like particle (VLP) capable of raising an immune response to an immunogen, and uses thereof, wherein the constructs comprise nucleic acid sequences encoding an immunogen and a polyprotein, wherein the polyprotein comprises two or more viral structural proteins, wherein at least two of the two or more viral structural proteins are separated by a signal peptidase sequence such that, when the polyprotein is expressed in a host cell, the signal peptidase sequence undergoes host cell peptidase-dependent cleavage to liberate the two or more viral structural proteins, thereby allowing the liberated structural proteins to self-assemble into a VLP carrying the immunogen.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |