发明申请
WO2023006971A1 SELECTIVE TOLERIZATION - METHODS OF SELECTIVELY GENERATING TOLEROGENIC DENDRITIC CELLS
审中-公开
基本信息:
- 专利标题： SELECTIVE TOLERIZATION - METHODS OF SELECTIVELY GENERATING TOLEROGENIC DENDRITIC CELLS
- 申请号：PCT/EP2022/071403 申请日：2022-07-29
- 公开(公告)号：WO2023006971A1 公开(公告)日：2023-02-02
- 发明人： EDELSON, Richard , HENCO, Karsten , SOBOLEV, Olga , HANLON, Douglas , VASSAL, Aaron , TATSUNO, Kazuki , HAN, Patrick
- 申请人： TRANSIMMUNE AG , YALE UNIVERSITY
- 申请人地址： Königsallee 90; Two Whitney Avenue
- 专利权人： TRANSIMMUNE AG,YALE UNIVERSITY
- 当前专利权人： TRANSIMMUNE AG,YALE UNIVERSITY
- 当前专利权人地址： Königsallee 90; Two Whitney Avenue
- 代理机构： MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH
- 优先权： EP21196099.2 2021-09-10
- 主分类号： C12N5/0784
- IPC分类号： C12N5/0784 ; A61K35/15 ; A61K31/00 ; C12N2501/48 ; C12N2502/115 ; C12N2502/1157 ; C12N2529/10 ; C12N5/064
摘要：
The present invention relates to methods of selectively generating tolerogenic dendritic cells. The present invention further relates to patient-specific tolerogenic dendritic cells obtained by the described methods which reduce immunogenicity of a transplant when administered prior to transplantation. The present invention also relates to patient-specific tolerogenic dendritic cells for use in reducing or preventing inflammatory conditions such as graft-versus-host disease. Specifically, the methods can be used to reduce graft versus host disease. The tolerogenic dendritic cells of the present invention can also be used for the treatment of autoimmune diseases.