基本信息:
- 专利标题： BAK ACTIVATORS, PHARMACEUTICAL COMPOSITIONS, AND USES IN TREATING CANCER
- 申请号：PCT/US2022/037783 申请日：2022-07-21
- 公开(公告)号：WO2023003990A1 公开(公告)日：2023-01-26
- 发明人： DENG, Xingming
- 申请人： EMORY UNIVERSITY
- 申请人地址： Office of Technology Transfer
- 专利权人： EMORY UNIVERSITY
- 当前专利权人： EMORY UNIVERSITY
- 当前专利权人地址： Office of Technology Transfer
- 代理机构： MASON, James C. et al.
- 优先权： US63/224,112 2021-07-21
- 主分类号： A61K31/33
- IPC分类号： A61K31/33 ; A61K31/4375 ; A61K31/4353
摘要：
This disclosure relates to activators of Bak, pharmaceutical compositions, and uses in treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of a Bak activator as disclosed herein to a human subject in need thereof. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a Bak activator which is 1-((2-((2-methoxyacridin-9-yl)amino)ethyl)amino)propan-2-ol (BKA-073), derivative, ester, or salt thereof and a pharmaceutically acceptable excipient.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |