发明申请
WO2022266235A1 NANOBODIES AGAINST SARS-COV-2 FOR DETECTION OF SARS-COV-2, AND DIAGNOSIS, TREATMENT AND PREVENTION OF INFECTION AND DISEASE CAUSED BY SARS-COV-2
审中-公开
基本信息:
- 专利标题： NANOBODIES AGAINST SARS-COV-2 FOR DETECTION OF SARS-COV-2, AND DIAGNOSIS, TREATMENT AND PREVENTION OF INFECTION AND DISEASE CAUSED BY SARS-COV-2
- 申请号：PCT/US2022/033651 申请日：2022-06-15
- 公开(公告)号：WO2022266235A1 公开(公告)日：2022-12-22
- 发明人： BRIESE, Thomas , LIPKIN, Walter, Ian , MISHRA, Nischay
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： 412 Low Memorial Library, 535 West 116th Street
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： 412 Low Memorial Library, 535 West 116th Street
- 代理机构： KRAMER CARNEY, Bonnie
- 优先权： US63/210,588 2021-06-15
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; C07K14/165 ; A61P31/12
摘要：
The current disclosure provides for polypeptides, single domain antibodies, VHHs and nanobodies which bind to or are directed against the SARS-CoV-2 virus, more specifically the spike protein of the SARS-CoV-2 virus. The disclosed VHHs and nanobodies can comprise a sequence selected from the sequences listed in Table 1 (SEQ ID NOs: 1-60), and fragments, derivatives and homologues thereof. The disclosure further provides for compositions comprising the anti-SARS-CoV-2 polypeptides, single domain antibodies, VHHs and nanobodies, and methods of making and using such for treatment, prevention, detection and diagnosis.