基本信息:
- 专利标题： IL-34 ANTISENSE AGENTS AND METHODS OF USING SAME
- 申请号：PCT/EP2022/063300 申请日：2022-05-17
- 公开(公告)号：WO2022243299A1 公开(公告)日：2022-11-24
- 发明人： VITI, Francesca , MCNULTY, Marie , BELLINVIA, Salvatore
- 申请人： NOGRA PHARMA LIMITED
- 申请人地址： 33 Sir John Rogerson's Quay
- 专利权人： NOGRA PHARMA LIMITED
- 当前专利权人： NOGRA PHARMA LIMITED
- 当前专利权人地址： 33 Sir John Rogerson's Quay
- 代理机构： HGF LTD
- 优先权： US63/201,887 2021-05-17
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/712 ; A61K31/7125 ; A61P29/00
摘要：
Disclosed herein polynucleotides complementary to IL-34, including IL-34 antisense oligonucleotides and IL-34 siRNAs, and methods for treating inflammatory diseases, such as an inflammatory bowel disease, and/or fibrosis, associated with elevated activity or expression of IL-34. Also disclosed are pharmaceutical compositions containing a polynucleotide complementary to IL-34, for example, an IL-34 antisense oligonucleotide or an IL-34 siRNA, useful for treating inflammatory diseases and/or fibrosis and manufacture of medicaments containing a disclosed polynucleotide to be used in treating inflammatory diseases and/or fibrosis.