基本信息:
- 专利标题： LIPID NANOPARTICLE THERAPEUTICS THAT EVADE THE IMMUNE RESPONSE
- 申请号：PCT/US2022/026998 申请日：2022-04-29
- 公开(公告)号：WO2022232552A1 公开(公告)日：2022-11-03
- 发明人： PARHIZ, Hamideh , WEISSMAN, Drew
- 申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 申请人地址： 3600 Civic Center Boulevard, 9th Floor
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人地址： 3600 Civic Center Boulevard, 9th Floor
- 代理机构： FONVILLE, Natalie et al.
- 优先权： US63/182,605 2021-04-30
- 主分类号： A61K47/59
- IPC分类号： A61K47/59 ; A61K51/12 ; C12N15/00
摘要：
The present invention relates to compositions and methods for effective delivery of a therapeutic agent to a subject using a delivery vehicle comprising a domain to evade the subject's immune response. In some embodiments, the present invention relates to compositions and methods for targeted delivery of a therapeutic agent to a subject using a delivery vehicle comprising a domain to evade the subject's immune response and a domain for targeting a specific cell type. The invention also relates to methods of use of the compositions of the invention for the treatment of diseases and disorders, including the treatment of diseases and disorders in subjects having an inflammatory or autoimmune disease or disorder.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/50 | .非有效成分被化学键合到有效成分上，例如聚合物－药物结合物 |
| ----------A61K47/51 | ..非有效成分为改性剂 |
| ------------A61K47/54 | ...该改性剂为有机化合物 |
| --------------A61K47/59 | ....由只涉及碳—碳不饱和键以外的反应获得的高分子化合物，例如聚脲或聚氨酯 |