基本信息:
- 专利标题： MODIFIED ORGANS AND TISSUES
- 申请号：PCT/CA2022/050625 申请日：2022-04-22
- 公开(公告)号：WO2022226632A1 公开(公告)日：2022-11-03
- 发明人： KESHAVJEE, Shafique , CYPEL, Marcelo , LIU, Mingyao , JUVET, Stephen , MESAKI, Kumi
- 申请人： UNIVERSITY HEALTH NETWORK
- 申请人地址： 190 Elizabeth Street
- 专利权人： UNIVERSITY HEALTH NETWORK
- 当前专利权人： UNIVERSITY HEALTH NETWORK
- 当前专利权人地址： 190 Elizabeth Street
- 代理机构： ALL THE PATENT AGENTS AT TORYS LLP
- 优先权： US63/180,365 2021-04-27
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; A61K31/7105 ; A61K35/12 ; A61K38/46 ; A61P29/00 ; A61P37/06 ; C12N5/10 ; C12N5/071 ; C12N15/09 ; C12N15/12 ; C12N15/19 ; C12N15/113
摘要：
The present disclosure relates generally to epigenetically and genetically modified organs and tissues and methods of producing same. In particular, the present disclosure is directed to organs and tissues that have been epigenetically and/or genetically modified at one or multiple loci to control inflammation-regulating or immune-regulating gene expression and thereby improve the condition of the organs and tissues.