发明申请
WO2022215020A1 1,3,4-OXADIAZOLE THIOCARBONYL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
审中-公开
基本信息:
- 专利标题： 1,3,4-OXADIAZOLE THIOCARBONYL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
- 申请号：PCT/IB2022/053253 申请日：2022-04-07
- 公开(公告)号：WO2022215020A1 公开(公告)日：2022-10-13
- 发明人： LEE, Chang Sik , OH, Jung Taek , SONG, Hyeseung , KIM, Hyunjin Michael
- 申请人： CHONG KUN DANG PHARMACEUTICAL CORP.
- 申请人地址： 8, Chungjeong-ro
- 专利权人： CHONG KUN DANG PHARMACEUTICAL CORP.
- 当前专利权人： CHONG KUN DANG PHARMACEUTICAL CORP.
- 当前专利权人地址： 8, Chungjeong-ro
- 代理机构： AHN, So Young
- 优先权： KR10-2021-0046134 2021-04-08
- 主分类号： C07D271/10
- IPC分类号： C07D271/10 ; A61K31/5377 ; A61K31/496 ; A61K31/541 ; C07D413/04 ; C07D413/12 ; C07D487/10 ; C07D491/107 ; C07D471/10
摘要：
The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a preparation method thereof, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by formula I.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D271/00 | 杂环化合物，含五元环，有两个氮原子和1个氧原子作为仅有的杂环原子 |
| --------C07D271/02 | .不和其他环稠合 |
| ----------C07D271/10 | ..1,3,4-二唑；氢化1,3,4-二唑 |