发明申请
WO2022204246A1 THERMOSTABLE D-GLUCARATE DEHYDRATASE THAT IS RESISTANT TO INHIBITION BY TARTRATE SEQUENCE SUBMISSION
审中-公开
基本信息:
- 专利标题： THERMOSTABLE D-GLUCARATE DEHYDRATASE THAT IS RESISTANT TO INHIBITION BY TARTRATE SEQUENCE SUBMISSION
- 申请号：PCT/US2022/021490 申请日：2022-03-23
- 公开(公告)号：WO2022204246A1 公开(公告)日：2022-09-29
- 发明人： BLAYLOCK, Bill , VENKITASUBRAMANIAN, Padmesh , WELCH, Mark , GOVINDARAJAN, Sridhar
- 申请人： ARCHER-DANIELS-MIDLAND COMPANY
- 申请人地址： 4666 Faries Parkway
- 专利权人： ARCHER-DANIELS-MIDLAND COMPANY
- 当前专利权人： ARCHER-DANIELS-MIDLAND COMPANY
- 当前专利权人地址： 4666 Faries Parkway
- 代理机构： ROBERTS, Mark
- 优先权： US63/166,361 2021-03-26
- 主分类号： C12P19/00
- IPC分类号： C12P19/00 ; C12P19/02 ; C12P17/04 ; C12P7/58 ; C12P7/62
摘要：
This disclosure provides glucarate dehydratase enzymes useful for commercial scale production of 5-keto-4-deoxy glucaric acid (KDG) from glucaric acid. The produced KDG may be dehydrated to form furan dicarboxylic acid (FDCA). The disclosed enzymes ("dehydratase variants") are variants of Lactipantibacillus pentous dehydratase engineered to have improved thermal tolerance and resistance to inhibition by tartrate as compared with the parent enzyme.
IPC结构图谱:
| C | 化学；冶金 |
| --C12 | 生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程 |
| ----C12P | 发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体 |
| ------C12P19/00 | 含有糖残基的化合物的制备 |