基本信息:
- 专利标题： ANTI-HER2 ANTIBODY-IMMUNE AGONIST CONJUGATE AND APPLICATIONS THEREOF
- 申请号：PCT/CN2022/079531 申请日：2022-03-07
- 公开(公告)号：WO2022188743A1 公开(公告)日：2022-09-15
- 发明人： SONG, Paul H. , QIN, Gang , YUAN, Jiandong , LIU, Chong
- 申请人： GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. , BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD.
- 申请人地址： 5th Floor, Building D, No. 398, Ruoshui Rd., Suzhou Industrial Park; Building C25, No. 218, Xinghu St., Biobay Suzhou Industrial Park
- 专利权人： GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.,BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD.
- 当前专利权人： GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.,BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD.
- 当前专利权人地址： 5th Floor, Building D, No. 398, Ruoshui Rd., Suzhou Industrial Park; Building C25, No. 218, Xinghu St., Biobay Suzhou Industrial Park
- 代理机构： NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.
- 优先权： CNPCT/CN2021/079611 2021-03-08
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07D471/04 ; A61P35/00
摘要：
The disclosure relates to a linking unit molecule for targeting molecule-drug conjugate, and the corresponding conjugate, the preparation and use thereof, and in particular relates to an anti-HER2 antibody-immune agonist conjugate (AIAC) as a novel type of cancer therapy.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/50 | .非有效成分被化学键合到有效成分上，例如聚合物－药物结合物 |
| ----------A61K47/66 | ..该改性剂是靶向特定细胞的涉及肽或蛋白质的预靶向系统 |
| ------------A61K47/68 | ...该改性剂是抗体、免疫球蛋白或其片段，例如Fc-片段 |