基本信息:
- 专利标题： 一种含EB病毒gHgL蛋白的自组装纳米颗粒及其制备方法与应用
- 专利标题（英）：SELF-ASSEMBLED NANOPARTICLE CONTAINING GHGL PROTEIN OF EB VIRUS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
- 申请号：PCT/CN2021/115968 申请日：2021-09-01
- 公开(公告)号：WO2022160709A1 公开(公告)日：2022-08-04
- 发明人： 曾木圣 , 孙聪 , 冯国开 , 康银峰
- 申请人： 中山大学 , 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所)
- 申请人地址： 中国广东省广州市海珠区新港西路135号, Guangdong 510275; 中国广东省广州市越秀区东风东路651号, Guangdong 510060
- 专利权人： 中山大学,中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所)
- 当前专利权人： 中山大学,中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所)
- 当前专利权人地址： 中国广东省广州市海珠区新港西路135号, Guangdong 510275; 中国广东省广州市越秀区东风东路651号, Guangdong 510060
- 代理机构： 广州嘉权专利商标事务所有限公司
- 优先权： CN202110117653.8 2021-01-28
- 主分类号： C07K14/03
- IPC分类号： C07K14/03 ; C12N15/38
A self-assembled nanoparticle containing a gHgL protein of an EB virus, and a preparation method therefor and the use thereof. The self-assembled nanoparticle contains a first polypeptide and a second polypeptide, wherein the first polypeptide contains a gHgL protein and a first carrier subunit; the second polypeptide contains a second carrier subunit; the first carrier subunit is I53-50A1; the second carrier subunit is I53-50B.4PT1; and the gHgL protein is hinged to the first carrier subunit. The gHgL protein of the EB virus is displayed on the surface of the self-assembled nanoparticle for the first time. The self-assembled nanoparticle has a larger particle size than the antigen (gHgL), has a better antigen residence volume, and has a thermal stability equivalent to the antigen (gHgL). Moreover, since the number of gHgL displayed is larger, the self-assembled nanoparticle can strongly stimulate more B cells and induce higher antibody titer, and can be used for preventing an EB virus infection and treating a disease caused by the EB virus infection.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/005 | .来自病毒 |
| ----------C07K14/01 | ..DNA病毒 |
| ------------C07K14/03 | ...疱疹病毒科，例如假性狂犬病病毒 |