发明申请
WO2022149998A1 METHOD OF OBTAINING A PHARMACEUTICAL AGENT USED FOR INHIBITING THE PROLIFERATION OF TUMOR CELLS
审中-公开
基本信息:
- 专利标题: METHOD OF OBTAINING A PHARMACEUTICAL AGENT USED FOR INHIBITING THE PROLIFERATION OF TUMOR CELLS
- 申请号:PCT/RU2022/050003 申请日:2022-01-10
- 公开(公告)号:WO2022149998A1 公开(公告)日:2022-07-14
- 发明人: SHIYAN, Lyudmila Nikolaevna , PUSTOVALOV, Alexey Vitalievich , BULDAKOV, Mikhail Alexandrovich , YURMAZOVA, Tatiana Alexandrovna , ZOTOV, Fedor Akexandrovich , SHVARTSMAN, Dmitry Igorevich , EVTINA, Anastasia Alekseevna
- 申请人: LIMITED LIABILITY COMPANY "LABORATORY OF INNOVATIVE TECHNOLOGIES"
- 申请人地址: mkr-n imeni Vladimira Makhalina, d. 20, office 302
- 专利权人: LIMITED LIABILITY COMPANY "LABORATORY OF INNOVATIVE TECHNOLOGIES"
- 当前专利权人: LIMITED LIABILITY COMPANY "LABORATORY OF INNOVATIVE TECHNOLOGIES"
- 当前专利权人地址: mkr-n imeni Vladimira Makhalina, d. 20, office 302
- 代理机构: PATENT & LAW FIRM 'YUS', LIMITED LIABILITY COMPANY
- 优先权: RU2021100394 2021-01-11
- 主分类号: A61K33/26
- IPC分类号: A61K33/26 ; A61P35/00 ; B22F9/14 ; B22F1/052 ; B22F1/054 ; B22F1/147 ; B22F2999/00 ; B82B3/00
摘要:
The given invention is related to the field of medicine, namely to experimental research in oncology, and can be used to obtain a pharmaceutical agent for inhibiting the proliferation of HeLa cervical cancer cells. It entails the use of a metal powder obtained in a gaseous medium by means of an electric explosion of a wire made of low-carbon steel carried out with a specific energy of 7-18 kJ/g and a pulse duration of 1.2-2 µs. The explosion is carried out inside a reactor that is pre-evacuated to a residual pressure of 10-2 Pa, and then filled with carbon monoxide to a pressure of 105 Pa at a gas circulation rate flow of 10 m/s. The products of the explosion deposited in a hopper are passivated in air for at least 48 hours. The resulting powder is extracted and mixed with a solution of the RPMI-1640 nutrient medium with L-glutamine, a pH of 7.2, in the proportion of the mass of the powder to the volume of the specified solution from 1:10 to 2.7: 10. The solution is then centrifuged until the phases are separated. The liquid phase is decanted and used as a pharmaceutical agent. The purpose of the given invention is to expand the arsenal of tools for inhibiting the proliferation of tumor cells.
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K33/00 | 含无机有效成分的医用配制品 |
--------A61K33/24 | .重金属;其化合物 |
----------A61K33/26 | ..铁;其化合物 |