发明申请
WO2022147620A1 THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF
审中-公开
基本信息:
- 专利标题： THIENYL AND CYCLOALKYL AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF
- 申请号：PCT/CA2022/050014 申请日：2022-01-07
- 公开(公告)号：WO2022147620A1 公开(公告)日：2022-07-14
- 发明人： AL-AWAR, Rima , ATTISANO, Liliana , ISAAC, Methvin , LIU, Yong , SMIL, David , UEHLING, David , WRANA, Jeff
- 申请人： ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , SINAI HEALTH SYSTEM
- 申请人地址： 661 University Avenue, Suite 510; Banting Institute, 100 College Street, Suite 413; 600 University Avenue
- 专利权人： ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR),THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO,SINAI HEALTH SYSTEM
- 当前专利权人： ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR),THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO,SINAI HEALTH SYSTEM
- 当前专利权人地址： 661 University Avenue, Suite 510; Banting Institute, 100 College Street, Suite 413; 600 University Avenue
- 代理机构： BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.
- 优先权： US63/134,739 2021-01-07
- 主分类号： C07D409/14
- IPC分类号： C07D409/14 ; A61K31/506 ; A61K31/551 ; A61K31/5383 ; A61P35/00 ; C07D239/48 ; C07D241/36 ; C07D409/12 ; C07D451/02 ; C07D471/10 ; C07D487/04 ; C07D498/04
摘要：
The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D409/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有硫原子作为仅有的杂环原子 |
| --------C07D409/14 | .含3个或更多个杂环 |