发明申请
WO2022147509A1 PREVENTION AND TREATMENT OF STEROID-RESISTANT OR GUT GRAFT-VERSUS-HOST DISEASE (GVHD)
审中-公开
基本信息:
- 专利标题： PREVENTION AND TREATMENT OF STEROID-RESISTANT OR GUT GRAFT-VERSUS-HOST DISEASE (GVHD)
- 申请号：PCT/US2022/011051 申请日：2022-01-03
- 公开(公告)号：WO2022147509A1 公开(公告)日：2022-07-07
- 发明人： ZENG, Defu , SONG, Qingxiao , RIGGS, Arthur, D.
- 申请人： CITY OF HOPE
- 申请人地址： 1500 East Duarte Road
- 专利权人： CITY OF HOPE
- 当前专利权人： CITY OF HOPE
- 当前专利权人地址： 1500 East Duarte Road
- 代理机构： TANG, Yang
- 优先权： US63/133,703 2021-01-04
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; A61P1/00 ; A61P37/06 ; C07K16/24
摘要：
Disclosed is a method of preventing or treating acute GVHD (aGVHD) such as gut aGVHD, steroid-resistant aGVHD, and steroid-resistant gut aGVHD in a subject receiving a hematopoietic cell transplantation (HCT) or autoimmune colitis by administering to the subject an effective amount of an anti-IL-22 antibody, an anti-IL-6 antibody, donor-type CX3CR1hi MNPs, donor-type NK cells, a ceacam-1 antagonist, an anti-Gr-1 antibody, or a combination thereof.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |