基本信息:
- 专利标题： TL1A THERAPY COMPOSITIONS AND METHODS OF TREATMENT THEREWITH
- 申请号：PCT/US2021/064406 申请日：2021-12-20
- 公开(公告)号：WO2022140283A1 公开(公告)日：2022-06-30
- 发明人： MCGOVERN, Dermot, P. , BILSBOROUGH, Janine , TARGAN, Stephan, R. , POTDAR, Alka
- 申请人： CEDARS-SINAI MEDICAL CENTER
- 申请人地址： 8700 Beverly Blvd.
- 专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人地址： 8700 Beverly Blvd.
- 代理机构： PENNEBAKER, Sara
- 优先权： US63/128,749 2020-12-21
- 主分类号： C07K14/525
- IPC分类号： C07K14/525 ; C12Q1/6883 ; A61P1/00
摘要：
Disclosed herein are methods, kits and compositions for treating an inflammatory disease or condition, or fibrosis in a subject that has been determined to have increased fold-change in Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) expression based, at least partially, on a presence of a combination of genotypes detected in a sample obtained from the subject. In some embodiments, the combination of genotypes is significantly associated with the increased fold-change in TL1A, and in some cases, may also be predictive of severe forms of the inflammatory disease or condition. In some embodiments, the inflammatory disease or condition is an inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/415 | .来自植物 |
| ----------C07K14/44 | ..来自原生动物门 |
| ------------C07K14/525 | ...肿瘤坏死因子（TNF） |