基本信息:
- 专利标题： TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS USING PKC ACTIVATORS
- 申请号：PCT/US2021/063437 申请日：2021-12-15
- 公开(公告)号：WO2022132856A1 公开(公告)日：2022-06-23
- 发明人： ALKON, Daniel L.
- 申请人： SYNAPTOGENIX, INC.
- 申请人地址： 205 East 42nd Street
- 专利权人： SYNAPTOGENIX, INC.
- 当前专利权人： SYNAPTOGENIX, INC.
- 当前专利权人地址： 205 East 42nd Street
- 代理机构： GROLZ, Edward W.
- 优先权： US63/126,020 2020-12-16
- 主分类号： A61K31/216
- IPC分类号： A61K31/216 ; A61K31/22 ; A61K31/235
摘要：
A method for treating or preventing amyotrophic lateral sclerosis (ALS) or other motor neuron disease in a subject, the method comprising administering to the subject a PKC activating compound (e.g., a bryostatin, such as bryostatin-1, or a bryolog) in a therapeutically effective amount to treat or prevent the motor neuron disease by activating PKC in the subject. The ALS may be, for example, classical ALS, primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), and progressive bulbar palsy (PBP). The PKC activating compound may be administered at an initial loading dose of about 15, 24, or 48 micrograms weekly in the first one week or consecutive two or three weeks, followed by doses of about 12, 20, or 40 micrograms alternately every two or three weeks for at least 4, 5, 6, 8, 10, 12, 14, 16, 18, 20, 24, or 30 total weeks.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/215 | ..羧酸酯 |
| ------------A61K31/216 | ...含芳环的酸的酯，例如胃复康、氯贝丁酯 |