基本信息:
- 专利标题： PHTHALAZINE DERIVATIVES AS P2X3 INHIBITORS
- 申请号：PCT/EP2021/083146 申请日：2021-11-26
- 公开(公告)号：WO2022112493A1 公开(公告)日：2022-06-02
- 发明人： FIORELLI, Claudio , BRUNO, Paolo , BIAGETTI, Matteo , BAKER-GLENN, Charles , VAN DE POËL, Hervè
- 申请人： CHIESI FARMACEUTICI S.P.A.
- 申请人地址： Via Palermo 26/A
- 专利权人： CHIESI FARMACEUTICI S.P.A.
- 当前专利权人： CHIESI FARMACEUTICI S.P.A.
- 当前专利权人地址： Via Palermo 26/A
- 优先权： EP20210200.0 2020-11-27
- 主分类号： A61P11/00
- IPC分类号： A61P11/00 ; C07D237/30 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D417/14 ; A61K31/502
摘要：
The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are phthalazine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P11/00 | 治疗呼吸系统疾病的药物 |