基本信息:
- 专利标题： 抗ＨＴＬＶ－１抗体
- 专利标题（英）：ANTI HTLV-1 ANTIBODY
- 申请号：PCT/JP2021/034714 申请日：2021-09-22
- 公开(公告)号：WO2022065344A1 公开(公告)日：2022-03-31
- 发明人： 田中 勇悦 , 吉村 千草 , 菅原 肇
- 申请人： 国立大学法人琉球大学 , 第一三共株式会社
- 申请人地址： 〒9030213 沖縄県中頭郡西原町字千原１番地 Okinawa; 〒1038426 東京都中央区日本橋本町三丁目５番１号 Tokyo
- 专利权人： 国立大学法人琉球大学,第一三共株式会社
- 当前专利权人： 国立大学法人琉球大学,第一三共株式会社
- 当前专利权人地址： 〒9030213 沖縄県中頭郡西原町字千原１番地 Okinawa; 〒1038426 東京都中央区日本橋本町三丁目５番１号 Tokyo
- 代理机构： 特許業務法人平木国際特許事務所
- 优先权： JP2020-159654 2020-09-24
- 主分类号： C12N15/13
- IPC分类号： C12N15/13 ; A61K39/395 ; A61P27/02 ; A61P31/14 ; A61P35/02 ; C07K16/10 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/63 ; C12P21/08
Provided are: an anti-HTLV-1 antibody for preventing the onset of, or treating, diseases caused by HTLV-1 in a person infected by HTLV-1, or preventing infection in a person not infected by HTLV-1; and a drug containing the antibody as an active ingredient. An antibody having the following properties (i)-(vi): (i) the antibody is a monoclonal antibody that recognizes and binds to an envelope protein gp46 of HTLV-1; (ii) the antibody recognizes an epitope comprising an amino acid sequence of amino acid sequence nos. 192-196 of the envelope protein gp46 of HTLV-1 represented by SEQ ID NO: 61; (iii) the binding dissociation constant (KD) with respect to HTLV-1 gp46 peptide nos. 180-204 is 50 nM or less; and (iv) the affinity with respect to six types of gp46 partial peptides in which amino acid sequence nos. 191-196 of the envelope protein gp46 of HTLV-1 represented by SEQ ID NO: 61 are substituted, for each residue respectively, with Ala is equivalent to that with respect to an unsubstituted gp46 partial peptide.