发明申请
WO2022051616A1 CDK TARGETED HETEROBIFUNCTIONAL SMALL MOLECULE PROTEOLYSIS TARGETING CHIMERAS
审中-公开
基本信息:
- 专利标题： CDK TARGETED HETEROBIFUNCTIONAL SMALL MOLECULE PROTEOLYSIS TARGETING CHIMERAS
- 申请号：PCT/US2021/049056 申请日：2021-09-03
- 公开(公告)号：WO2022051616A1 公开(公告)日：2022-03-10
- 发明人： NATARAJAN, Amarnath , RANA, Sandeep
- 申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 申请人地址： Varner Hall, 3835 Holdrege Street
- 专利权人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 当前专利权人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 当前专利权人地址： Varner Hall, 3835 Holdrege Street
- 代理机构： BURNETTE, Jennifer et al.
- 优先权： US63/074,054 2020-09-03
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07K5/083 ; A61P35/00
摘要：
Provided herein are compounds and methods for selectively degrading cycl in¬ dependent kinases (CDKs). More particularly, provided are compounds that selectively degrade CDKs and the uses of such compounds in regulating diseases and disorders, e.g., to treat cancer, inflammatory diseases, and neurological diseases.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/04 | ..邻位稠合系 |