基本信息:
- 专利标题： SEROLOGICAL ANTIBODY-BASED DIAGNOSTICS OF SARS-COV-2 INFECTION
- 申请号：PCT/EP2021/067755 申请日：2021-06-28
- 公开(公告)号：WO2022022927A1 公开(公告)日：2022-02-03
- 发明人： WHITE, Michael , MUELLER, Ivo , ROSADO SANDOVAL, Javier Jason , PELLEAU, Stéphane , BACKOVIC, Marija , PETRES, Stéphane , WOUDENBERG, Tom , BRUEL, Timothée
- 申请人： INSTITUT PASTEUR , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
- 申请人地址： 25 - 28 Rue du Docteur Roux; 1G Royal parade
- 专利权人： INSTITUT PASTEUR,THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
- 当前专利权人： INSTITUT PASTEUR,THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
- 当前专利权人地址： 25 - 28 Rue du Docteur Roux; 1G Royal parade
- 代理机构： PLASSERAUD IP
- 优先权： US63/057,471 2020-07-28
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; C07K14/165 ; C07K14/005 ; C12N2770/20022 ; G01N2333/165 ; G01N33/6854
摘要：
The invention relates to compositions, kits, statistical algorithms and methods for the immunodetection of antibodies against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in biological samples such as human blood samples. The invention encompasses compositions, kits, statistical algorithms and methods comprising SARS-CoV-2 trimeric Spike protein and combinations of SARS-CoV-2 antigens. The SARS-CoV-2 trimeric Spike protein and combinations of SARS-CoV-2 antigens provide for improved detection of antibodies against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in biological samples such as human blood samples.