基本信息:
- 专利标题： SMALL MOLECULE INHIBITORS OF TDP-43 ACTIVITY AND USES THEREOF
- 申请号：PCT/US2021/041852 申请日：2021-07-15
- 公开(公告)号：WO2022015997A2 公开(公告)日：2022-01-20
- 发明人： KHANNA, May , GOKHALE, Vijay , FRANCOIS-MOUTAL, Liberty , SCOTT, David , WILLIAMS, Haley , TELLO, Judith , MOLLASALEHI, Niloufar
- 申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
- 申请人地址： The University of Arizona, Tech Launch Arizona, University Services Annex, 4th Floor, P.O. Box 210300A
- 专利权人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
- 当前专利权人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
- 当前专利权人地址： The University of Arizona, Tech Launch Arizona, University Services Annex, 4th Floor, P.O. Box 210300A
- 代理机构： GOETZ, Robert A.
- 优先权： US63/052,163 2020-07-15
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61K31/42 ; C07D261/18 ; C07D413/12 ; A61K31/553
摘要：
This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of TDP-43 activity. The invention further relates to methods of treating and/or ameliorating symptoms related to conditions associated with TDP-43 activity (e.g., neurodevelopmental disorders), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of TDP-43 activity.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/165 | ..含芳环的，例如秋水仙碱、阿替洛尔、氟柳双胺 |