基本信息:
- 专利标题: 펩시노겐 II의 수준을 측정하는 제제를 포함하는 초기 미만형 위암 예측 또는 진단용 조성물
- 专利标题(英):COMPOSITION FOR PREDICTING OR DIAGNOSING EARLY-STAGE DIFFUSE GASTRIC CANCER, COMPRISING PREPARATION FOR MEASURING LEVEL OF PEPSINOGEN II
- 申请号:PCT/KR2020/012575 申请日:2020-09-17
- 公开(公告)号:WO2022014776A1 公开(公告)日:2022-01-20
- 发明人: 김나영
- 申请人: 서울대학교병원
- 申请人地址: 03080 서울시 종로구 대학로 101, Seoul
- 专利权人: 서울대학교병원
- 当前专利权人: 서울대학교병원
- 当前专利权人地址: 03080 서울시 종로구 대학로 101, Seoul
- 代理机构: 최우성
- 优先权: KR10-2020-0086191 2020-07-13
- 主分类号: G01N33/574
- IPC分类号: G01N33/574 ; G01N33/569 ; C12Q1/04 ; C12Q1/58
The present invention relates to a composition, kit and information provision method, for discovering pepsinogen II as a biomarker for predicting or diagnosing early-stage diffuse gastric cancer, and enabling predicting or diagnosing early-stage diffuse gastric cancer according to the level of pepsinogen II measured in a subject. The composition, kit and information provision method, according to one aspect of the present invention, may predict or diagnose early-stage diffuse gastric cancer with high sensitivity and specificity when the level of serum pepsinogen II is equal to or greater than 20 µg/L, and further, may classify the risk of early-stage diffuse gastric cancer in a subject on the basis of whether the level of serum pepsinogen II is equal to or greater than 20 µg/L, and whether the status of Helicobacter pylori (HP) is positive. Thus, the composition, comprising a preparation capable of measuring the level of serum pepsinogen II, or, along with said preparation, a preparation capable of detecting the status of HP, the kit and the information provision method using same have an excellent effect of being capable of being usefully employed as non-invasive means which may be carried out prior to an endoscopy.
IPC结构图谱:
G | 物理 |
--G01 | 测量;测试 |
----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
------G01N33/00 | 利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料 |
--------G01N33/48 | .生物物质,例如血、尿(G01N33/02至G01N33/14,G01N33/26,G01N33/44,G01N33/46优先;种子发芽能力测定入A01C1/02);血球计数器 |
----------G01N33/483 | ..生物物质的物理分析 |
------------G01N33/53 | ...免疫测定法;生物特有的结合方法的测定;相应的生物物质 |
--------------G01N33/574 | ....用于癌症 |