基本信息:
- 专利标题： METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS
- 申请号：PCT/US2021/039077 申请日：2021-06-25
- 公开(公告)号：WO2021263097A2 公开(公告)日：2021-12-30
- 发明人： FIORINA, Paolo , BIFFI, Alessandra
- 申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 申请人地址： 55 Shattuck Street
- 专利权人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人： THE CHILDREN'S MEDICAL CENTER CORPORATION
- 当前专利权人地址： 55 Shattuck Street
- 代理机构： RESNICK, David S. et al.
- 优先权： US63/044,590 2020-06-26
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; A61P25/00 ; C12N5/0789 ; C12N5/10 ; A01K2227/105 ; A01K2267/0318 ; A61K38/00 ; A61K48/005
摘要：
The disclosed invention provides a method of treating a central nervous system (CNS) disease or disorder comprising administering to a subject diagnosed with the CNS disease or disorder a composition comprising a population of genetically modified, programmed cell death-1 receptor ligand (PD-L1)+-expressing hematopoietic stem cells (HSCs),wherein the CNS disease or disorder involves inflammation of the CNS. In one embodiment, the CNS disease or disorder is Multiple Sclerosis (MS). In certain aspects, the hematopoietic stem cells (HSCs) are obtained from a subject having a CNS disease or disorder prior to modification.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K35/00 | 含有其有不明结构的原材料或其反应产物的医用配制品 |
| --------A61K35/02 | .来源于非生命物质的 |
| ----------A61K35/28 | ..骨髓；脾 |