发明申请
WO2021257033A1 GENETIC MOLECULE ENCAPSULATION IN MESOPOROUS SILICA/POLYETHYLENE GLYCOL HYBRID STRUCTURE
审中-公开
基本信息:
- 专利标题： GENETIC MOLECULE ENCAPSULATION IN MESOPOROUS SILICA/POLYETHYLENE GLYCOL HYBRID STRUCTURE
- 申请号：PCT/TR2021/050584 申请日：2021-06-14
- 公开(公告)号：WO2021257033A1 公开(公告)日：2021-12-23
- 发明人： KAPUSUZ, Derya , DURUCAN, Caner
- 申请人： GAZIANTEP UNIVERSITESI REKTORLUGU , ORTA DOGU TEKNIK UNIVERSITESI
- 申请人地址： Üniversite Bulvarı; Üniversiteler Mahallesi Dumlupınar Bulvarı No:1
- 专利权人： GAZIANTEP UNIVERSITESI REKTORLUGU,ORTA DOGU TEKNIK UNIVERSITESI
- 当前专利权人： GAZIANTEP UNIVERSITESI REKTORLUGU,ORTA DOGU TEKNIK UNIVERSITESI
- 当前专利权人地址： Üniversite Bulvarı; Üniversiteler Mahallesi Dumlupınar Bulvarı No:1
- 代理机构： FULYA SUMERALP-SIMAJ PATENT CONSULTING LIMITED
- 优先权： TR2020/09223 2020-06-15
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/11 ; C12N15/88 ; C01B33/18
摘要：
The present invention is an encapsulation method for transporting the genetic molecule in a preservative material, most generally, comprises the following process steps of adding alcohol to a silica source and polyethylene glycol source and mixing and obtaining two separate solutions, adding the polyethylene glycol solution to the silica solution, mixing and adding water to hydrolyze the solution, during condensation, just before gelling, in order to transport inside the pores of the amorphous structure formed, adding a genetic molecule in its buffer solution to the hydrolyzed solution or adding the hydrolyzed solution to a genetic molecule in its buffer solution and then obtaining a gel, obtaining a dry gel by drying/aging the gel and powdering the dry gel. Hybrid material of the mesoporous silica/polyethylene glycol and silica/polyethylene glycol/polyethyleneimine, carrying the genetic molecule inside, obtained by this method, is also covered by the scope of invention.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K48/00 | 含有插入到活体细胞中的遗传物质以治疗遗传病的医药配制品；基因治疗 |