基本信息:
- 专利标题： ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF
- 申请号：PCT/US2021/036657 申请日：2021-06-09
- 公开(公告)号：WO2021252661A1 公开(公告)日：2021-12-16
- 发明人： SCOTT, David A. , GERO, Thomas , BEYETT, Tyler , HEPPNER, David , GIPSON, Krista E. , HUANG, Shih-Chung , STROUD, Steve
- 申请人： DANA-FARBER CANCER INSTITUTE, INC. , SCOTT, David A. , GERO, Thomas , BEYETT, Tyler , HEPPNER, David , GIPSON, Krista E. , HUANG, Shih-Chung , STROUD, Steve
- 申请人地址： 450 Brookline Avenue; 109 Walnut Hill Road; 265 West Acton Road; 70 Centre Street; 14 Marion Street; 42 Marion Street; 58 Ivan Street; 2022 East 40 Landsdowne Street
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.,SCOTT, David A.,GERO, Thomas,BEYETT, Tyler,HEPPNER, David,GIPSON, Krista E.,HUANG, Shih-Chung,STROUD, Steve
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.,SCOTT, David A.,GERO, Thomas,BEYETT, Tyler,HEPPNER, David,GIPSON, Krista E.,HUANG, Shih-Chung,STROUD, Steve
- 当前专利权人地址： 450 Brookline Avenue; 109 Walnut Hill Road; 265 West Acton Road; 70 Centre Street; 14 Marion Street; 42 Marion Street; 58 Ivan Street; 2022 East 40 Landsdowne Street
- 代理机构： TRINQUE, Brian C.
- 优先权： US63/036,622 2020-06-09
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D241/08 ; C07D513/04 ; A61P35/00 ; C07D401/14 ; C07D487/04 ; C07D495/04
摘要：
The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/4985 | ....与杂环邻位或迫位稠合的吡嗪或哌嗪 |