基本信息:
- 专利标题： CORONAVIRUS VACCINE COMPOSITIONS, METHODS, AND USES THEREOF
- 申请号：PCT/CN2021/093895 申请日：2021-05-14
- 公开(公告)号：WO2021249116A1 公开(公告)日：2021-12-16
- 发明人： LIANG, Peng , LIANG, Joshua
- 申请人： SICHUAN CLOVER BIOPHARMACEUTICALS, INC.
- 申请人地址： Room B-A10, Building No. 1, Chengdu Hi-Tech Zone Tianhe Incubation Park
- 专利权人： SICHUAN CLOVER BIOPHARMACEUTICALS, INC.
- 当前专利权人： SICHUAN CLOVER BIOPHARMACEUTICALS, INC.
- 当前专利权人地址： Room B-A10, Building No. 1, Chengdu Hi-Tech Zone Tianhe Incubation Park
- 代理机构： CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE
- 优先权： CNPCT/CN2020/095269 2020-06-10
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/00 ; A61K38/00 ; A61P31/00 ; A61K2039/55505 ; A61K2039/6031 ; A61K2039/64 ; A61K39/12 ; A61P31/14 ; C07K14/005 ; C12N2770/20034 ; C12N2770/20071 ; G01N33/68
摘要：
Provided are recombinant peptides and proteins which comprise coronavirus viral antigens and immunogens, e.g., coronavirus S protein peptides. In some aspects, the immunogenic composition comprises a secreted fusion protein comprising a soluble coronavirus viral antigen joined by in-frame fusion to a C-terminal portion of a collagen which is capable of self-trimerization to form a disulfide bond-linked trimeric fusion protein. In some aspects, the immunogenic compositions provided herein are useful for generating an immune response, e.g., for treating or preventing a coronavirus infection. In some aspects, the immunogenic compositions provided herein may be used in a vaccine composition, e.g., as part of a prophylactic and/or therapeutic vaccine. Also provided herein are methods for producing the recombinant peptides and proteins, prophylactic, therapeutic, and/or diagnostic methods, and related kits.