基本信息:
- 专利标题： NOVEL LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF
- 申请号：PCT/US2021/032676 申请日：2021-05-17
- 公开(公告)号：WO2021236479A2 公开(公告)日：2021-11-25
- 发明人： STANTON, Matthew, G. , NOLTING, Birte
- 申请人： GENERATION BIO CO.
- 申请人地址： 301 Binney Street, 4th Floor
- 专利权人： GENERATION BIO CO.
- 当前专利权人： GENERATION BIO CO.
- 当前专利权人地址： 301 Binney Street, 4th Floor
- 代理机构： CLARKE, Marcie, B. et al.
- 优先权： US63/026,479 2020-05-18
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K9/51 ; C07C323/25
摘要：
Provided herein are lipids having the Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R1', R2, R2', R3, R3', R4, R4', R5, and R5' are as defined herein. Also provided herein are lipid nanoparticle (LNP) compositions comprising lipid having the Formula (I) and a capsid-free, non-viral vector (e.g., ceDNA). In one aspect, these LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).
公开/授权文献:
- WO2021236479A8 NOVEL LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF 公开/授权日：2021-11-25
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/127 | ..脂质体 |