基本信息:
- 专利标题： MODIFIED KISSPEPTIN RECEPTOR AGONISTS FOR FATTY LIVER DISEASE
- 申请号：PCT/US2021/070363 申请日：2021-04-08
- 公开(公告)号：WO2021207759A1 公开(公告)日：2021-10-14
- 发明人： BHATTACHARYA BABWAH, M. Moshmi , VIDESH BABWAH, Andy , RADOVICK, Sally , WONDISFORD, Fredric E.
- 申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- 申请人地址： 83 Somerset Street
- 专利权人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- 当前专利权人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- 当前专利权人地址： 83 Somerset Street
- 代理机构： MOLINELLI, Eugene J.
- 优先权： US63/007,071 2020-04-08
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/17 ; A61K38/22 ; A61K38/28 ; C07K14/435 ; C07K14/575 ; A61P5/48 ; A61P1/16 ; A61P5/50
摘要：
Kisspeptin 1 receptor (KISS1R) is a G protein-coupled receptor which binds the 54-AA peptide hormone kisspeptin (metastin). TAK-448 is a potent Kisspeptin 1 receptor (KISS1R, or GPR54) agonist. Kisspeptin and KISS1R in the brain play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. This specification discusses results that implicate the peripheral kisspeptin/Kiss1R pathway in the pathogenesis of non-alcoholic fatty liver disease and provide a method of reducing fat in the liver.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/16 | .含有20个以上氨基酸的肽；胃泌激素；生长素抑制素；促黑激素；其衍生物 |