发明申请
WO2021069672A1 COMPOSITION FOR REPROGRAMMING CELLS INTO PLASMACYTOID DENDRITIC CELLS OR INTERFERON TYPE I-PRODUCING CELLS, METHODS AND USES THEREOF
审中-公开
基本信息:
- 专利标题： COMPOSITION FOR REPROGRAMMING CELLS INTO PLASMACYTOID DENDRITIC CELLS OR INTERFERON TYPE I-PRODUCING CELLS, METHODS AND USES THEREOF
- 申请号：PCT/EP2020/078429 申请日：2020-10-09
- 公开(公告)号：WO2021069672A1 公开(公告)日：2021-04-15
- 发明人： RIBEIRO, LEMOS, PEREIRA, Carlos, Filipe , FERREIRA, PIRES, Cristiana , FIÚZA, ROSA, Fábio
- 申请人： ASGARD THERAPEUTICS AB
- 申请人地址： c/o Cristiana Pires
- 专利权人： ASGARD THERAPEUTICS AB
- 当前专利权人： ASGARD THERAPEUTICS AB
- 当前专利权人地址： c/o Cristiana Pires
- 代理机构： HØIBERG P/S
- 优先权： PT115833 2019-10-10
- 主分类号： C12N5/0784
- IPC分类号： C12N5/0784 ; A61K38/17 ; C07K14/47 ; A61K35/15
摘要：
The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof. The present disclosure relates to the development of methods for making plasmacytoid dendritic cells or interferon type I-producing cells that promote antiviral and anti-tumoral immune responses from differentiated, multipotent or pluripotent stem cells by introducing and expressing isolated/synthetic transcription factors. More particularly, the disclosure provides methods for obtain plasmacytoid dendritic cells or interferon type I-producing cells by direct cellular reprogramming with the surprisingly use of combinations of specific transcription factors.