发明申请
WO2021050708A1 BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION
审中-公开
基本信息:
- 专利标题： BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION
- 申请号：PCT/US2020/050173 申请日：2020-09-10
- 公开(公告)号：WO2021050708A1 公开(公告)日：2021-03-18
- 发明人： FUJITANI, Manabu , IWAKI, Tsutomu , NAKAMURA, Rina , MILLER, Marvin J. , MORASKI, Garrett C.
- 申请人： SHIONOGI & CO., LTD. , HSIRI THERAPEUTICS, INC.
- 申请人地址： 1-8, Doshomachi 3-chome, Chuo-ku; 1400 N. Providence Road, Building 1, Suite 115S
- 专利权人： SHIONOGI & CO., LTD.,HSIRI THERAPEUTICS, INC.
- 当前专利权人： SHIONOGI & CO., LTD.,HSIRI THERAPEUTICS, INC.
- 当前专利权人地址： 1-8, Doshomachi 3-chome, Chuo-ku; 1400 N. Providence Road, Building 1, Suite 115S
- 代理机构： FREISTEIN, Andrew B.
- 优先权： US62/898,066 2019-09-10
- 主分类号： A61P31/04
- IPC分类号： A61P31/04 ; C07D471/04 ; A61K31/437 ; A61K31/4545 ; A61K31/496 ; A61K31/498 ; A61K31/499 ; A61K31/4995
摘要：
A compound represented by formula (I):, or its pharmaceutically acceptable salt, wherein a group represented by formula: (II) is a group represented by formula: (III) or (IV); R1 is each independently halogen, hydroxy, cyano or the like; m is 0, 1, 2, 3 or 4; R2 is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like; R3a, R3b, R3c and R3d are each independently hydrogen atom, halogen or the like, with the proviso that R3a, R3b, R3c and R3d are not simultaneously hydrogen atom; ring C is represented as follows: (V), (VI), (VII), (VIII), (IX) or (X). X is CH or N; Y is CH or N; R4 is each independently halogen, hydroxy, cyano or the like; p is 0 or 1; q is 0, 1, 2, 3 or 4; R5 is CR5C or N; R6 is CR6C or N; R7 is CR7C or N; R8 is CR8C or N; R9 is CR9C or N; with the proviso that R5, R6, R7, R8 and R9 are not simultaneously N; R5C, R6C, R7C, R8C and R9C are each independently hydrogen atom or the like.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P31/00 | 抗感染药，即抗生素、抗菌剂、化疗剂 |
| --------A61P31/04 | .抗细菌药 |