基本信息:
- 专利标题： 一种手性β-羟基酸酯化合物的制备方法
- 专利标题（英）：METHOD FOR PREPARING CHIRAL β-HYDROXYLCARBOXYLATE COMPOUND
- 申请号：PCT/CN2019/104631 申请日：2019-09-06
- 公开(公告)号：WO2021031246A1 公开(公告)日：2021-02-25
- 发明人： 胡信虎 HU, Xinhu , 呼延旺 HU, YanWang
- 申请人： 上海欣海国际贸易有限公司 , 胡信虎 , 呼延旺
- 申请人地址： 中国上海市浦东新区东明路2000号308室, Shanghai 201206; 中国上海市浦东新区东明路2000号308室, Shanghai 200125; 中国上海市浦东新区东明路2000号308室, Shanghai 201206
- 专利权人： 上海欣海国际贸易有限公司,胡信虎,呼延旺
- 当前专利权人： 上海欣海国际贸易有限公司,胡信虎,呼延旺
- 当前专利权人地址： 中国上海市浦东新区东明路2000号308室, Shanghai 201206; 中国上海市浦东新区东明路2000号308室, Shanghai 200125; 中国上海市浦东新区东明路2000号308室, Shanghai 201206
- 代理机构： 上海翰信知识产权代理事务所（普通合伙）
- 优先权： CN201910777137.0 2019-08-22
- 主分类号： C07C67/31
- IPC分类号： C07C67/31 ; B01J31/24 ; C07C69/732 ; C07C69/675
The present application discloses a method for preparing a chiral β-hydroxylcarboxylate compound, involving firstly dissolving a dichlorophenyl ruthenium dimer, a ligand and an alkaline additive in a solvent under the protection of an inert gas, and stirring same at room temperature to produce a catalyst in situ; and then dissolving the substrate β-carbonylcarboxylate in a solvent, adding same to the prepared catalyst, introducing hydrogen and subjecting the substrate β-carbonylcarboxylate to an asymmetric catalytic hydrogenation reaction, wherein the reaction conditions are as follows: the pressure is 10-100 atmospheres, the reaction temperature is 0-200ºC, and the reaction time is 12-48 hours. The invention has a high reaction activity and selectivity, mild hydrogenation reaction conditions, is suitable for a variety of β-carbonylcarboxylates, and has a wide substrate application range and a small amount of environmental pollution created during the reaction process.