发明申请
WO2020236690A1 NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES
审中-公开
基本信息:
- 专利标题： NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES
- 申请号：PCT/US2020/033356 申请日：2020-05-18
- 公开(公告)号：WO2020236690A1 公开(公告)日：2020-11-26
- 发明人： BENNETT, Frank , IMBRIGLIO, Jason, E. , KEREKES, Angela, D. , KHAN, Tanweer , LANKIN, Claire , LI, Derun , WU, Zhicai , XIONG, Yusheng , YOUM, Hyewon , YU, Yang , KURISSERY, Anthappan Tony , KOMANDURI, Venukrishnan , YE, Feng
- 申请人： MERCK SHARP & DOHME CORP. , BENNETT, Frank , IMBRIGLIO, Jason, E. , KEREKES, Angela, D. , KHAN, Tanweer , LANKIN, Claire , LI, Derun , WU, Zhicai , XIONG, Yusheng , YOUM, Hyewon , YU, Yang , KURISSERY, Anthappan Tony , KOMANDURI, Venukrishnan
- 申请人地址： 126 East Lincoln Avenue; 2000 Galloping Hill Road; 2000 Galloping Hill Road; 2000 Galloping Hill Road; 21 Forest Avenue; 2000 Galloping Hill Road; 33 Avenue Louis Pasteur; 2000 Galloping Hill Road; 60 Bradford Lane; 2000 Galloping Hill Road; 2000 Galloping Hill Road; Flat F3-802, SNN RAJ; 21 Egerton Court
- 专利权人： MERCK SHARP & DOHME CORP.,BENNETT, Frank,IMBRIGLIO, Jason, E.,KEREKES, Angela, D.,KHAN, Tanweer,LANKIN, Claire,LI, Derun,WU, Zhicai,XIONG, Yusheng,YOUM, Hyewon,YU, Yang,KURISSERY, Anthappan Tony,KOMANDURI, Venukrishnan
- 当前专利权人： MERCK SHARP & DOHME CORP.,BENNETT, Frank,IMBRIGLIO, Jason, E.,KEREKES, Angela, D.,KHAN, Tanweer,LANKIN, Claire,LI, Derun,WU, Zhicai,XIONG, Yusheng,YOUM, Hyewon,YU, Yang,KURISSERY, Anthappan Tony,KOMANDURI, Venukrishnan
- 当前专利权人地址： 126 East Lincoln Avenue; 2000 Galloping Hill Road; 2000 Galloping Hill Road; 2000 Galloping Hill Road; 21 Forest Avenue; 2000 Galloping Hill Road; 33 Avenue Louis Pasteur; 2000 Galloping Hill Road; 60 Bradford Lane; 2000 Galloping Hill Road; 2000 Galloping Hill Road; Flat F3-802, SNN RAJ; 21 Egerton Court
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US62/851,534 2019-05-22
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K31/415 ; A61K31/4155 ; A61K31/473 ; A61K31/501 ; A61K31/5377 ; A61K45/06 ; A61P3/10 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D491/107 ; C07D498/08
摘要：
The present invention relates to Compounds of Formula I: I and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of cardiometabolic diseases including high blood pressure, heart failure, kidney disease, and diabetes in a subject.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/41 | ...有两个或两个以上环杂原子的五元环的，其中至少有1个氮原子，例如四唑 |