基本信息:
- 专利标题： COMPOSITE BIOMATERIALS
- 申请号：PCT/CA2020/050655 申请日：2020-05-14
- 公开(公告)号：WO2020227835A1 公开(公告)日：2020-11-19
- 发明人： HICKEY, Ryan , PELLING, Andrew E. , CAMPUZANO, Santiago , DE SOUSA FARIA TISCHER, Paula Cristina , SZERESZEWSKI, Kama
- 申请人： SPIDERWORT INC. , UNIVERSITY OF OTTAWA
- 申请人地址： 7 Bayview Road; 800 King Edward Avenue
- 专利权人： SPIDERWORT INC.,UNIVERSITY OF OTTAWA
- 当前专利权人： SPIDERWORT INC.,UNIVERSITY OF OTTAWA
- 当前专利权人地址： 7 Bayview Road; 800 King Edward Avenue
- 代理机构： NEWTON, Trevor et al.
- 优先权： US62/847,619 2019-05-14
- 主分类号： C12N5/04
- IPC分类号： C12N5/04 ; A23L29/00 ; A23L33/00 ; A61K47/38 ; A61K47/46 ; A61K9/10 ; A61L27/50 ; A61L27/52 ; A61L27/54 ; B01D11/02 ; B33Y80/00 ; C08J3/075 ; C08J3/24 ; C08J5/12 ; C08L1/02 ; C09J5/00 ; C12N1/14 ; C12N5/00 ; C12N5/07 ; C12N5/077 ; A23L13/00 ; A23L17/00 ; A23L15/00 ; A23L19/09 ; A23L29/20 ; A23L31/00 ; A61L27/34 ; A61L27/3637 ; A61L27/3683 ; A61L27/3826 ; A61L27/48 ; B01D11/0257 ; B01D11/0288 ; C08J2301/02 ; C09D105/04 ; C09D105/08 ; C09D105/12 ; C09D189/06 ; C12N2533/54 ; C12N2533/78 ; C12N2533/90 ; C12N2537/10 ; C12N5/0062
摘要：
Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure, the two or more scaffold biomaterial subunits being assembled into the composite scaffold biomaterial and held together via gel casting using a hydrogel glue; via complementary interlocking geometry of the two or more scaffold biomaterial subunits; via guided assembly based biolithography (GAB); via chemical cross-linking; or any combinations thereof. Methods for producing such scaffold biomaterials, as well as methods and uses thereof, are also provided.