基本信息:
- 专利标题： SENSORS FOR DETECTING AND IMAGING OF CANCER METASTASIS
- 申请号：PCT/US2020/014007 申请日：2020-01-17
- 公开(公告)号：WO2020150560A1 公开(公告)日：2020-07-23
- 发明人： BHATIA, Sangeeta, N. , HAO, Liangliang
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 申请人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 77 Massachusetts Avenue Cambridge, MA 02139 US
- 代理机构： LOCKHART, Helen, C. et al.
- 优先权： US62/793,805 20190117
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; G01N33/543 ; G01N33/58 ; G01N33/60
摘要：
In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of cancer. In some embodiments, the disclosure relates to protease imaging sensors comprising a scaffold linked to an enzyme- specific substrate that includes a first detectable marker capable of being released from the prostate protease sensor when exposed to an enzyme present in cancer and a tumor imaging agent comprising a second detectable marker that is linked to the scaffold. In some embodiments, the disclosure relates to methods of monitor progression of a tumor in a subject based upon detection of detectable markers in a sample obtained from a subject who has been administered a protease imaging sensor, upon detection of a tumor imaging agent, or any combination thereof.